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Table 1 Genes involved in GPI-anchor biosynthesis and their mutant alleles

From: Simulation and estimation of gene number in a biological pathway using almost complete saturation mutagenesis screening of haploid mouse cells

   

No. of mutant alleles

Gene

Chr

CDS length (bp)

H129-2

HAP-1

Total

Pigc

1

891

2

2

4

Pigm

1

1269

5

4

9

Pign

1

2793

NA*

NA*

NA*

Dpm1

2

780

2†

3

5

Dpm2

2

252

0

1

1

Pigt

2

1746

4

4

8

Pigu

2

1305

10

3

13

Dpm3

3

276

0

1

1

Pigk

3

1185

7

1

8

Pigo

4

3303

5

4

9

Pigv

4

1479

5†

6

11

Pigg

5

2925

NA*

NA*

NA*

Pgap2

7

750

1

3

4

Pigb

9

1626

7

3

10

Pigy

9

213

0

0

0

Mpdu1

11

741

0

0

0

Pigl

11

756

3

1

4

Pigs

11

1665

3

0

3

Pigw

11

1509

1

1

2

Pigh

12

564

1

0

1

Gpaa1

15

1863

6

1

7

Pigp

16

396

1

1

2

Pigx

16

756

6

3

9

Pigf

17

657

2

2

4

Pigq

17

1743

NA*

NA*

NA*

Piga

X

1455

NA*

NA*

NA*

  

(Total)

71

44

115

  1. *Four genes excluded from screening targets (see text).
  2. †One H129-2 clone has two mutant alleles (see Table 2 and Figure 2).
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BMC Genomics

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