Gene expression profiles during early morphogenesis of deciduous molars and successional dental lamina. (A) The third deciduous molar (Dm3) in the mandible of the miniature pig is in the cap stage at E40 (no successional dental lamina), bell stage at E50 (lingual successional dental lamina appearing, red arrowhead), and secretory stage at E60 (successional dental lamina changes little). Scale bar, 500 μm. (B) Venn diagrams showing the stage-specific gene expression profiling at E40, E50, and E60, with each section showing the gene expression number. (C) The genes with differential expression between stages, with down-regulated genes being predominant on E50 versus E40, while up-regulated genes were more dominant when comparing E60 versus E50. (D) Venn diagrams showing the numbers and type (up-, down- or contra-regulated) of transcriptional alterations between stages.