Table 2 The 25 most down-regulated genes after 60 min of potassium starvation (P < 0.01)
From: Transcriptional response of Saccharomyces cerevisiae to potassium starvation
Annotation | Description | RNA level 50 mM (reads per million) (± SD; n = 4) | RNA level 0 mM (reads per million) (± SD; n = 4) | Fold-change (50 mM/0 mM) | P-value |
|---|---|---|---|---|---|
YIL171W-A | Dubious open reading frame | 0.6 ± 0.2 | 0.0 ± 0.0 | - | 0.001 |
RER1 | Protein involved in retention of membrane proteins | 0.5 ± 0.2 | 0.0 ± 0.0 | - | 0.001 |
CLB6 | B-type cyclin involved in DNA replication during S phase | 23 ± 10 | 0.3 ± 0.4 | 71.2 | 0.004 |
TOS6 | Glycosylphosphatidylinositol-dependent cell wall protein | 395 ± 42 | 12 ± 9 | 32.5 | 0.000 |
POL30 | Proliferating cell nuclear antigen | 166 ± 46 | 5.7 ± 4.0 | 29.1 | 0.000 |
PCL1 | Cyclin, interacts with cyclin-dependent kinase Pho85p | 100 ± 30 | 4.1 ± 3.4 | 24.6 | 0.001 |
TOS4 | Putative transcription factor, contains Forkhead Associated domain | 54 ± 15 | 2.5 ± 2.4 | 21.3 | 0.001 |
KCC4 | Protein kinase of the bud neck involved in the septin checkpoint | 42 ± 14 | 2.1 ± 1.4 | 20.3 | 0.001 |
YMR230W-A | Putative protein of unknown function | 23 ± 11 | 1.1 ± 1.0 | 20.1 | 0.007 |
YOX1 | Homeobox transcriptional repressor | 71 ± 21 | 4.1 ± 3.1 | 17.2 | 0.001 |
HTA1 | Histone H2A | 1248 ± 392 | 74 ± 31 | 17.0 | 0.001 |
CDC45 | DNA replication initiation factor | 27 ± 9 | 1.9 ± 1.3 | 14.1 | 0.002 |
SWE1 | Protein kinase that regulates the G2/M transition | 81 ± 35 | 6.8 ± 4.7 | 11.9 | 0.006 |
CDC21 | Thymidylate synthase | 98 ± 34 | 8.3 ± 5.9 | 11.8 | 0.002 |
ALG14 | Component of UDP-GlcNAc transferase | 76 ± 26 | 6.7 ± 4.6 | 11.4 | 0.002 |
YIG1 | Protein that interacts with glycerol 3-phosphatase | 1.5 ± 0.5 | 0.1 ± 0.3 | 10.7 | 0.003 |
MCD1 | Essential alpha-kleisin subunit of the cohesin complex | 87 ± 30 | 8.4 ± 5.2 | 10.4 | 0.002 |
RPL18B | Ribosomal 60S subunit protein L18B | 774 ± 132 | 75 ± 13 | 10.4 | 0.000 |
LSM4 | Lsm (Like Sm) protein | 0.9 ± 0.2 | 0.1 ± 0.2 | 10.2 | 0.001 |
GAP1 | General amino acid permease | 146 ± 18 | 15 ± 6 | 9.6 | 0.000 |
YER088C-A | Dubious open reading frame | 24 ± 5 | 2.6 ± 1.8 | 9.4 | 0.000 |
YLR413W | Putative protein of unknown function | 207 ± 58 | 22 ± 11 | 9.4 | 0.001 |
TOS2 | Protein involved in localization of Cdc24p to the site of bud growth | 16 ± 1 | 1.7 ± 1.5 | 9.2 | 0.000 |
PMI40 | Mannose-6-phosphate isomerase | 361 ± 96 | 40 ± 29 | 9.1 | 0.001 |
KIP1 | Kinesin-related motor protein | 21 ± 7 | 2.3 ± 1.6 | 8.9 | 0.002 |