Table 4 Functional analysis using FunSpec[22] of genes down-regulated at least 2-fold (P < 0.01) during potassium starvation
From: Transcriptional response of Saccharomyces cerevisiae to potassium starvation
Category | p-value (x10−3) | In category from cluster | ka | fa |
|---|---|---|---|---|
cell division [GO:0051301] | 0.007 | LTE1 KIP1 HSL7 KCC4 MCD1 UBC9 PDS1 SPC25 CLB1 CLB6 SWE1 PCL1 SGO1 NUD1 CLN2 CLB5 KAR3 | 17 | 190 |
regulation of cyclin-dependent protein kinase activity [GO:0000079] | 0.008 | CLB1 CLB6 SWE1 PCL1 CLN2 CLB5 | 6 | 20 |
cell cycle [GO:0007049] | 0.019 | LTE1 KIP1 HSL7 KCC4 MCD1 PSA1 UBC9 PDS1 SPC25 CLB1 CLB6 SWE1 SLD2 CDC45 YOX1 TOF1 PCL1 SGO1 NUD1 CLN2 CLB5 KAR3 | 22 | 316 |
mitosis [GO:0007067] | 0.15 | LTE1 KIP1 HSL7 MCD1 UBC9 PDS1 SPC25 CLB1 SWE1 SGO1 NUD1 KAR3 | 12 | 132 |
ammonia assimilation cycle [GO:0019676] | 0.16 | GAP1 PUT4 GDH1 | 3 | 5 |
amino acid transmembrane transport [GO:0003333] | 0.31 | GNP1 HNM1 GAP1 BIO5 PUT4 | 5 | 24 |
double-strand break repair via break-induced replication [GO:0000727] | 0.46 | RDH54 SLD5 SLD2 CDC45 CTF4 | 5 | 26 |
DNA replication [GO:0006260] | 0.66 | POL12 POL30 SLD5 SLD2 CDC45 TOF1 RFA2 CTF4 | 8 | 75 |
G2/M transition of mitotic cell cycle [GO:0000086] | 0.67 | HSL7 UBC9 CLB1 SWE1 CLB5 | 5 | 28 |
positive regulation of DNA replication [GO:0045740] | 0.67 | CLB6 CLB5 | 2 | 2 |
GDP-mannose biosynthetic process [GO:0009298] | 0.67 | PSA1 PMI40 | 2 | 2 |
meiotic mismatch repair [GO:0000710] | 0.87 | POL30 MSH6 PMS1 | 3 | 8 |
budding cell bud growth [GO:0007117] | 1.00 | KCC4 GIN4 TOS2 DFG5 | 4 | 18 |
'de novo' IMP biosynthetic process [GO:0006189] | 1.28 | ADE17 ADE4 ADE2 | 3 | 9 |
microtubule nucleation [GO:0007020] | 1.84 | SPC25 SPC97 STU2 SPC98 | 4 | 21 |
gamma-aminobutyric acid transport [GO:0015812] | 1.97 | GAP1 PUT4 | 2 | 3 |
regulation of S phase of mitotic cell cycle [GO:0007090] | 1.97 | CLB6 CLB5 | 2 | 3 |
mitotic sister chromatid cohesion [GO:0007064] | 3.08 | POL30 TOF1 CTF4 KAR3 | 4 | 24 |
cell wall mannoprotein biosynthetic process [GO:0000032] | 3.16 | PSA1 PMI40 KTR1 | 3 | 12 |
glycine metabolic process [GO:0006544] | 3.87 | SHM2 GCV2 | 2 | 4 |
septin checkpoint [GO:0000135] | 3.87 | KCC4 GIN4 | 2 | 4 |
amino acid transport [GO:0006865] | 4.30 | GNP1 HNM1 GAP1 BIO5 PUT4 | 5 | 42 |
response to DNA damage stimulus [GO:0006974] | 4.92 | RDH54 POL30 MCD1 DUN1 MSH6 HTA1 SRS2 TOS4 OGG1 PMS1 TOF1 SMC5 | 12 | 197 |
telomere maintenance via telomerase [GO:0007004] | 6.17 | EST1 RAP1 RFA2 | 3 | 15 |
DNA repair [GO:0006281] | 7.71 | RDH54 POL30 MSH6 HTA1 SRS2 OGG1 PMS1 TOF1 RFA2 SMC5 CTF4 | 11 | 183 |
negative regulation of transcription from RNA polymerase II promoter, global [GO:0045816] | 9.34 | HTB1 HTA1 | 2 | 6 |
regulation of mitotic cell cycle [GO:0007346] | 9.34 | SMI1 YOX1 | 2 | 6 |
premeiotic DNA replication [GO:0006279] | 9.34 | CLB6 CLB5 | 2 | 6 |
replication fork protection [GO:0048478] | 9.34 | DUN1 TOF1 | 2 | 6 |