Figure 7

p63 functions with multiple cooperating TFs. (A) A correlation matrix for the 13 probable p63 cooperating TFs at the 11,632 p63 locations. Upper triangle shows Pearson’s correlation coefficient calculated between ChIP-Seq tag densities for each pair of TFs. For BACH1 and FOSL2, ChIP-Seq signal are from K562 and A549 cell-lines respectively. While for the rest of the 11 factors, ChIP-Seq signal is from Hela-S3 cell-line. Lower triangle shows correlation between motif scores generated by Patser. (B) The 11632 p63 bound locations are clustered by the presence (purple) or absence (yellow) of the 10 cooperating TFs motifs (CEBPB, AP1, BACH1, AP2, STAT1, STAT3, MYCMAX, USF, RFX, ELK1), in a 1 kb window centered at p63 binding site.