Assessment of transcriptomic similarity. Hypergeometric testing was conducted on all pairs of tissues to identify similar transcriptomic profiles (A). Spot size represents the magnitude of the calculated gene enrichment ratio while the background shade denotes q-values obtained from hypergeometric testing. Genes not probed on the array are represented by “X”. Venn diagrams of commonly altered genes between all tissues (B), rat tissues (C) and liver tissues (D).