Network motifs. The two most prominent motifs found to be significantly conserved across the three species. A selection of Gene Ontology subnetworks were the motif had a top 20% Z-score in all species is listed below each motif (Z-score is given for each species). A an exhaustive list of GOs are given in Additional file 4. (A) Two connected transcription factors (TFs) regulating the same gene (feed-forward loop). (B) Two unconnected TFs regulating the same two genes (bi-fan motif).