Figure 1
Molecular characterization of acutely exposed mice liver. (A) Heatmap showing the expression profiles in Ctrl, U and D waters treated mice livers. The expression value of each gene is mapped to a colour-intensity value, as indicated by the colour bar. (B) Venn Diagram showing the probe sets overlap in U (orange) and D (blue) groups compared to the control. (C) Canonical pathways, identified by IPA analysis, deregulated in liver of U and D waters exposed mice. The left y-axis value is the negative lg10(Benjamini-Hochberg corrected p-value). The orange squares referred to the right y-axis represent the ratio values indicating the percentage of genes in the pathway that are also deregulated. (D) Toxfunctions deregulated in U and D exposed animal livers. (E) qRT-PCR validation of some DEGs. Data are reported as the negative inverse of fold change value calculated as ratio between average expression in U/D and in Ctrl exposed animals (8 animals/group).