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Figure 7 | BMC Genomics

Figure 7

From: Novel and unique domains in aminoacyl-tRNA synthetases from human fungal pathogens Aspergillus niger, Candida albicans and Cryptococcus neoformans

Figure 7

Sequence and structural analyses for tyrosyl-tRNA synthetase from C. neoformans. (A) Comparison of domain architectures for C. neoformans TyrRS (CNBA1270) and H. sapiens cytoplasmic TyrRS based on the Pfam domain assignment. SAICAR domain at the C-terminal of C. neoformans TyrRS is absent in the homolog from H. sapiens and these two TyrRSs are ~47% identical in the TyrRS catalytic domain region. (B) Superimposition of modeled C. neoformans SAICAR domain in TyrRS (magenta) and crystal structure of SAICAR synthase (PDB ID 2CNQ) from Saccharomyces cerevisiae (green) with adenosine-di-phosphate (ADP, blue). The two proteins share 51% sequence identity. Inset shows sequence and structural conservation of ADP interacting residue in the two proteins.

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BMC Genomics

ISSN: 1471-2164

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