Novel and unique domains in aminoacyl-tRNA synthetases from human fungal pathogens Aspergillus niger, Candida albicans and Cryptococcus neoformans

Table 3 ORFs in C. neoformans having aaRS or associated domains

	aaRS domain	ORF	Predicted sub-cellular localization	Protein length	E-value for HMM prediction	Identity with human homolog (%)
Class I	ArgRS	CNBG3480	Cyto	622	NA	37
	CysRS	CNBB4810	Cyto	785	0	42
	GlnRS	CNBA0720	Cyto	858	5.2e-300	40
	GluRS	CNBK2470	Mito	588	2.3e-197	35
	GluRS	CNBF4640	Cyto	728	3.1e-295	43
	IleRS	CNBA2140	Cyto_nucl	1094	0	51
	IleRS	CNBN1610	Mito	1032	0	36
	LeuRS	CNBM1150	Cyto	1114	0	46
	MetRS	CNBD2070	Cyto	724	0	46
	TrpRS	CNBJ3070	Mito	641	5.5e-221	55
	TyrRS	CNBA1270	Cyto	819	3.3e-218	47
	TyrRS	CNBJ0260	Mito	478	1.2e-169	47
	ValRS	CNBB3840	Mito	1109	0	47
Class II	AlaRS	CNBF2180	Mito	1012	0	49
	AsnRS	CNBD2410	Mito	513	1.7e-157	38
	AsnRS	CNBE1330	Cyto	600	1.8e-251	48
	AspRS	CNBK1200	Mito	693	8.5e-193	36
	AsxRS	CNBG4380	Cyto	884	0	42
	GlyRS	CNBF3810	Cyto	673	0	46
	HisRS	CNBC0810	Mito	586	4.2e-270	47
	LysRS	CNBH3030	Mito	630	0	52
	PheRS	CNBC0600	Mito	476	4.5e-214	40
	PheRS α	CNBJ1210	Cyto	510	1.1e-250	51
	PheRS β	CNBC3360	Nucl	632	4.1e-283	44
	ProRS	CNBB0150	Mito	740	0	55
	SerRS	CNBD0870	Cyto	461	2.6e-225	40
	ThrRS	CNBB5220	Mito	772	0	56
aaRS related proteins	AlaX	CNBA4150	Cyto	523	1.1e-108	29
	DTD	CNBB3530	Cyto	234	1e-41	47
	P43 homolog	CNBF3180	Cyto	383	1.8e-124	47
	Asn synthase	CNBK3010	Mito	572	1.7e-196	34
	Asn synthase	CNBL0870	Mito	592	1.6e-65	34
	GatA	CNBD1400	Mito	493	1.7e-119	33
	GatB	CNBG4210	Mito	521	1.7e-176	37

NA in e-value indicates fungal sequences that could be identified by HMM search and were retrieved from NCBI using keyword search.

ISSN: 1471-2164