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Figure 6 | BMC Genomics

Figure 6

From: In vivo genome-wide analysis of multiple tissues identifies gene regulatory networks, novel functions and downstream regulatory genes for Bapx1 and its co-regulation with Sox9 in the mammalian vertebral column

Figure 6

A gene regulatory network in vertebral column driven by Bapx1 and Sox9 . (A) Three layer mechanism of genomic control in the vertebral column by Bapx1 and Sox9. Bapx1 suppresses neuronal genes whereas Sox9 activates them; both activate chondrogenic genes whereas both suppress genes involved in osteogenesis, cartilage degradation and blood vessel development. (B) A large gene regulatory network in the vertebral column of genes that are either activated (green lines) or repressed (red lines) by Sox9 and Bapx1. Each blue dot represents a gene and the common regulated genes are in the center on the network connected to both Sox9 and Bapx1.

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BMC Genomics

ISSN: 1471-2164

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