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Table 1 Genes forming a hotspot of eQTL mapping on THI3

From: Deciphering regulatory variation of THI genes in alcoholic fermentation indicate an impact of Thi3p on PDC1 expression

Gene Name LODscore QTL position sens Cis-eQTL Function
YDL087C LUC7 17,56 chr4:304kbp 59A + Yes Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5 splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA
YDR438W THI74 5,32 chr4:306kbp 59A +   Mitochondrial transporter repressible by thiamine
YCR020C PET18 4,32 chr4:310kbp 59A +   Protein required for respiratory growth and stability of the mitochondrial genome
YJR156C THI11 7,95 chr4:310kbp 59A +   Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5 THI11 THI12 and THI13
YNL332W THI12 8,55 chr4:310kbp 59A +   Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5 THI11 THI12 and THI13
YDL244W THI13 5,83 chr4:310kbp 59A +   Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5 THI11 THI12 and THI13
YDL079C MRK1 4,23 chr4:310kbp 59A - Yes Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes
YLR044C PDC1 6,12 chr4:319kbp 59A -   Major of three pyruvate decarboxylase isozymes key enzyme in alcoholic fermentation decarboxylates pyruvate to acetaldehyde
YNL331C AAD14 5,55 chr4:319kbp 59A +   Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role
YDR541C YDR541C 6,00 chr4:326kbp 59A +   Putative dihydrokaempferol 4-reductase
YGL186C TPN1 6,26 chr4:326kbp 59A +   Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily