Table 1 Genes forming a hotspot of eQTL mapping on THI3

YDL087C

LUC7

17,56

chr4:304kbp

59A +

Yes

Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5 splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA

YDR438W

THI74

5,32

chr4:306kbp

59A +

Mitochondrial transporter repressible by thiamine

YCR020C

PET18

4,32

chr4:310kbp

59A +

Protein required for respiratory growth and stability of the mitochondrial genome

YJR156C

THI11

7,95

chr4:310kbp

59A +

Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5 THI11 THI12 and THI13

YNL332W

THI12

8,55

chr4:310kbp

59A +

Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5 THI11 THI12 and THI13

YDL244W

THI13

5,83

chr4:310kbp

59A +

Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5 THI11 THI12 and THI13

YDL079C

MRK1

4,23

chr4:310kbp

59A -

Yes

Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes

YLR044C

PDC1

6,12

chr4:319kbp

59A -

Major of three pyruvate decarboxylase isozymes key enzyme in alcoholic fermentation decarboxylates pyruvate to acetaldehyde

YNL331C

AAD14

5,55

chr4:319kbp

59A +

Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role

YDR541C

YDR541C

6,00

chr4:326kbp

59A +

Putative dihydrokaempferol 4-reductase

YGL186C

TPN1

6,26

chr4:326kbp

59A +

Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily