Figure 8
An integrated picture of PPARα biology. Gene functional categories identified in the “PPARα tailored analysis” were integrated into a simplified concept of hepatic PPARα biology. The picture represents a hepatocyte and organelles such as lipid droplets (yellow spheres), Golgi, transport vesicles (irregular blue spheres), nucleus, mitochondria, peroxisomes (regular light blue spheres), and trafficking FFA (black figures symbolizing hydrophobic and hydrophilic parts of FFA). Text boxes contain the identified functional categories and arrows indicate direction of changes of the significant genes (FDR ≤ 0.05) within the gene functional categories.