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Table 1 General characteristics of DNA methylation in different species

From: Genome-wide and single-base resolution DNA methylomes of the Pacific oyster Crassostrea gigas provide insight into the evolution of invertebrate CpG methylation

Species Tissue % of mC in genomic cytosines % of mCG in genomic CpGs % of mC in different sequence context % of genes being methylated Level of gene body methylation Data sources
CG CHG CHH
Inbred oyster Mantle 1.95 15.96 99.56 0.08 0.36 54 0.20 N/A
Wild oyster Mantle 1.96 16.25 99.69 0.06 0.25 58 0.18 N/A
Silkworm Silk gland 0.11 0.56 99.24 0.14 0.62 47 0.02 [8]
Honeybee Adult brain 0.11 0.36 97.36 0.10 2.54 61 0.01 [9]
Ant Embryo 0.15 0.54 99.25 0.03 0.72 31 0.02 [10]
Sea anemone Whole adult 1.44 10.89 99.93 0.02 0.05 51 0.16 [5]
Sea squirt Muscle 4.07 28.95 99.94 0.01 0.05 71 0.34 [5]
Human Peripheral blood 3.93 82.08 92.40 0.70 6.90 97 0.68 [11]
  1. Note: For sequence context of CHG or CHH, H represents A, T or C. When calculating the percentage of mC out of total genomic cytosines or mCGs out of total genomic CpGs, only C or CpG positions with ≥ 2X coverage were considered. Methylated genes were defined as genes with ≥ 2 identified mCGs. Only genes with ≥ 70% coverage were used for gene-related calculation, and only CpG positions with ≥ 5X coverage were used for gene body methylation level estimation. Species used for comparison are the oyster Crassostrea gigas, silkworm Bombyx mori, honeybee Apis mellifera, ant Camponotus floridanus, sea anemone Nematostella vectensis, sea squirt Ciona intestinalis and human Homo sapiens.