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Table 3 Selected differentially expressed genes in fast muscle of exercised adult zebrafish that participate in angiogenesis, immune-related processess and metabolism

From: Swimming-induced exercise promotes hypertrophy and vascularization of fast skeletal muscle fibres and activation of myogenic and angiogenic transcriptional programs in adult zebrafish

Gene name gene description FC Gene name gene description FC
Angiogenesis   Energy metabolism  
klf2 Kruppel-like factor 2 (lung) 8.52 cpt1a Carnitine palmitoyltransferase 1A (liver) 5.23
robo2 Roundabout, axon guidance receptor, homolog 2 (Drosophila) 4.30 pfkm Phosphofructokinase, muscle 3.84
angpt2 Angiopoietin 2 3.90 prkaaq Protein kinase, AMP-activated, alpha 1 cat. 3.66
angptl3 Angiopoietin-like 3 3.47 elovl4 ELOVL fatty acid elongase 4 3.65
efna3 Ephrin-A3 3.45 prkag1 Protein kinase, AMP-activated, gamma 1 catalytic subunit 3.50
gata1 GATA binding protein 1 (globin transcription factor 1) 3.00 acadl Acyl-CoA dehydrogenase, long chain 3.20
epha4 EPH receptor A4 2.96 ppard Peroxisome proliferator-activated receptor d 3.19
nrp1 Neuropilin 1 2.89 aldoa Aldolase A, fructose-bisphosphate 3.18
mmp14 Matrix metallopeptidase 14 (membrane-inserted) 2.69 mcat Malonyl CoA:ACP acyltransferase (mitochondrial) 3.14
nos1 Nitric oxide synthase 1 (neuronal) 2.65 slc27a2 Solute carrier family 27 (fatty acid transporter), member 2 3.10
notch1 Notch 1 2.60 prkab1 Protein kinase, AMP-activated, beta 1 non-catalytic subunit 3.06
sema3f Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 2.57 mb Myoglobin 2.95
slit3 Slit homolog 3 (Drosophila) 2.53 cox7c Cytochrome c oxidase subunit VIIc 2.85
amot Angiomotin 2.34 ppara Peroxisome proliferator-activated receptor alpha 2.77
hey2 Hairy/enhancer-of-split related with YRPW motif 2 2.20 tfb2m Transcription factor B2, mitochondrial 2.42
tp63 Tumor protein p63 2.16 fbp1 Fructose-1,6-bisphosphatase 1 2.39
mmp10 Matrix metallopeptidase 10 (stromelysin 2) 2.06 g6pc Glucose-6-phosphatase, catalytic subunit 2.38
s1pr1 Sphingosine-1-phosphate receptor 1 2.03 pdha1 Pyruvate dehydrogenase (lipoamide) alpha 1 2.24
ephb4 EPH receptor B4 1.97 ckm Creatine kinase, muscle 2.24
nr2f2 Nuclear receptor subfamily 2, group F, member 2 1.95 fh Fumarate hydratase 2.20
efnb3 Ephrin-B3 1.94 ogdh Oxoglutarate hydrogenase (lipoamide) 2.19
hif3a Hypoxia inducible factor 3, alpha subunit 1.92 gapdh Glyceraldehyde-3-phosphate dehydrogenase 2.19
epha7 EPH receptor A7 1.91 adh5 Alcohol dehydrogenase 5 (class III) 2.18
angptl2 Angiopoietin-like 2 1.90 cox5a Cytochrome c oxidase subunit Va 2.12
nos2 Nitric oxide synthase 2, inducible 1.85 pgk1 Phosphoglycerate kinase 1 2.02
cdc42ep2 CDC42 effector protein (Rho GTPase binding) 2 1.83 fads6 Fatty acid desaturase 6 1.99
efna2 Ephrin-A2 1.83 mdh2 Malate dehydrogenase 2, NAD (mitochondrial) 1.97
nr2f1 Nuclear receptor subfamily 2, group F, member 1 1.83 cox6a2 Cytochrome c oxidase subunit VIa polypeptide 2 1.97
jag1 Jagged 1 1.80 ndufv1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 1.94
slit2 Slit homolog 2 (Drosophila) 1.79 fabp3 Fatty acid binding protein 3, muscle and heart 1.94
hey1 Hairy/enhancer-of-split related with YRPW motif 1 1.78 slcad Solute carrier family 2 (facilitated glucose transporter), member 2 1.92
hif1an Hypoxia inducible factor 1, alpha subunit inhibitor 1.73 atp5h ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d 1.91
foxc1 Forkhead box C1 1.68 ucp3 Uncoupling protein 3 (mitochondrial ) 1.88
efnb2 Ephrin-B2 1.63 cpt2 Carnitine palmitoyltransferase 2 1.86
jag2 Jagged 2 1.54 ndufb1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa 1.82
vegfc Vascular endothelial growth factor C 1.36 ckmt2 Creatine kinase, mitochondrial 2 (sarcomeric) 1.82
dll1 Delta-like 1 (Drosophila) −1.25 mdh1 Malate dehydrogenase 1, NAD (soluble) 1.77
rac1 Ras-related C3 botulinum toxin substrate 1 −1.57 sdha Succinate dehydrogenase complex, subunit A, 1.74
rock2 Rho-associated, coiled-coil containing protein kinase 2 −1.61 mt-atp6 ATP synthase F0 subunit 6 1.70
notch2 Notch 2 −1.89 acacb Acetyl-CoA carboxylase beta 1.70
cdc42 Cell division cycle 42 −1.97 ucp2 Uncoupling protein 2 (mitochondrial) 1.68
aggf1 Angiogenic factor with G patch and FHA domains 1 −2.10 atp5o ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit 1.68
Immune-related factors   eno1 Enolase 1, (alpha) 1,68
traf6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 10.78 cox4i1 Cytochrome c oxidase subunit IV isoform 1 1.68
il17D Interleukin 17D 6.51 cox7a2l Cytochrome c oxidase subunit VIIa polypeptide 2 like 1.67
ptgs1 Prostaglandin-endoperoxide synthase 1 5.81 atp5f1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 1.65
irak1bp1 Interleukin-1 receptor-associated kinase 1 BP 1 4.98 nrf1 Nuclear respiratory factor 1 1.62
irf3 Interferon regulatory factor 3 4.60 ldhb Lactate dehydrogenase B 1.60
il29ra Interleukin 20 receptor, alpha 3.91 adipor2 Adiponectin receptor 2 1.56
il12b Interleukin 12B 3.68 lpl Lipoprotein lipase −1.51
il11ra Interleukin 11 receptor, alpha 3.24 eifsb4 Eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa −1.58
ptgr1 Prostaglandin reductase 1 3.21 gpi Glucose-6-phosphate isomerase −1.76
ptgds Prostaglandin D2 synthase 21kDa (brain) 3.18 ndufaf4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 −1.88
ptgis Prostaglandin I2 (prostacyclin) synthase 2.87 aldoc Aldolase C, fructose-bisphosphate −2.03
il13ra2 Interleukin 13 receptor, alpha 2 2.54 pkm Pyruvate kinase, muscle −2.24
il20 Interleukin 20 2.44 hk2 Hexokinase 2 −2.36
tnfrsf19 Tumor necrosis factor receptor superfamily, member 19 2.43 Protein synthesis and degradation  
nkrf NFKB repressing factor 1.77 pdk2 Pyruvate dehydrogenase kinase, isozyme 2 6.87
il17rd Interleukin 17 receptor D 1.74 fbxo32 F-box protein 32 6.01
mst1 Macrophage stimulating 1 (hepatocyte growth factor-like) 1.66 pdk1 Pyruvate dehydrogenase kinase, isozyme 1 2.19
mif Macrophage migration inhibitory factor (glycosylation-inhibiting factor) −1.50 foxo3 Forkhead box O3 2.08
ilf3 Interleukin enhancer binding factor 3, 90kDa −1.77 trim63 Tripartite motif containing 63, E3 ubiquitin protein ligase 2.02
ptges3 Prostaglandin E synthase 3 (cytosolic) −2.29 rps6ka1 Ribosomal protein S6 kinase, 90kDa, polypeptide 1 1.96
il21r Interleukin 21 receptor −2,59 eif4e Eukaryotic translation initiation factor 4E −1,89
irak4 Interleukin-1 receptor-associated kinase 4 −2,68 eif4ebp1 Eukaryotic translation initiation factor 4E binding protein 1 −2,01
  1. Data are shown as fold change (FC).
  2. Functional categories are indicated in bold.