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Table 4 Significantly over-represented putative canonical pathways in fast muscle of exercised zebrafish

From: Swimming-induced exercise promotes hypertrophy and vascularization of fast skeletal muscle fibres and activation of myogenic and angiogenic transcriptional programs in adult zebrafish

Ingenuity canonical pathways p-Value Ratio
Integrin Signaling 3.28E-16 94/208
Protein Ubiquitination Pathway 3.62E-12 103/268
Wnt/β-catenin Signaling 5.57E-11 75/175
mTOR Signaling 6.06E-06 68/211
TGF-β Signaling 7.22E-06 36/89
Ephrin B Signaling 2.46E-05 32/82
Actin Cytoskeleton Signaling 3.04E-05 72/239
IGF-1 Signaling 6.53E-05 38/105
Glycolysis 1.01E-04 14/41
VEGF Signaling 1.03E-04 36/104
AMPK Signaling 4.67E-04 46/169
Calcium Signaling 6.03E-04 58/213
Insulin Receptor Signaling 1.22E-03 44/142
FGF Signaling 1.53E-03 31/92
Chemokine Signaling 1.72E-03 26/73
PI3K/AKT Signaling 1.75E-03 41/144
Fatty Acid β-oxidation 1.99E-03 14/45
Hypoxia Signaling in the Cardiovascular System 4.35E-03 24/67
PDGF Signaling 4.63E-03 27/85
HIF1α Signaling 9.07E-03 33/108
Notch Signaling 9.60E-03 15/43
Angiopoietin Signaling 3.00E-02 21/74
  1. The associated p-value (Fisher’s exact test P < 0.05) and the ratio of the number of differentially expressed genes in fast muscle of exercised zebrafish over the total number of genes in each particular pathway in the Ingenuity Knowledge Base. Canonical pathway names are from Ingenuity Systems.