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Table 1 Genes differentially regulated in A. gossypii during the production of recombinant EGI (FDR of 4.4%)

From: Investigation of protein secretion and secretion stress in Ashbya gossypii

 

A. gossypiigene

S. cerevisiaehomolog(s)

Predicted protein function

Biological processes

Up-regulated

AAR030W

CTR1

High-affinity copper transporter

Amino acid transport

 

AAR080W

No homolog

Unknown

 
 

ADL123C

PHO4

Transcription factor that activates transcription cooperatively with Pho2p in response to phosphate limitation

 
 

ADL153W

RRI2

Subunit of the COP9 signalosome complex

 
 

ADR080W

FRE1

Ferric reductase and cupric reductase

Iron transmembrane transport

 

AEL294C

FTR1

High-affinity iron permease

 
 

AER428W

OM45

Major constituent of the mitochondrial outer membrane

 
 

AFL135W

YMR181C, YPL229W

Unknown

 
 

AFR156W

PUT4

High-affinity proline permease

Transmembrane transport

 

AFR442C

PHO84

High-affinity inorganic phosphate transporter and low-affinity manganese transporter

 
 

AFR529W

SUC2

Invertase

 
 

AFR595W

MCH1

Protein with similarity to mammalian monocarboxylate permeases

 
 

AFR668W

CAN1, ALP1

Plasma membrane arginine permease

Ion transport

 

AFR739C

No homolog

Unknown

 
 

AGL097C

ENA2, ENA5, ENA1

P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance

 
 

AGR304W

MTH1, STD1

Protein involved in the control of glucose-regulated gene expression

 

Down-regulated

ABL065W

RPG1

Subunit of the core complex of translation initiation factor 3 (eIF3)

Regulation of translation

 

ABL174C

SSB2, SSB1

Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family

Posttranscriptional regulation of gene expression

 

AEL032W

GCN20

Positive regulator of the Gcn2 kinase activity

Regulation of cellular protein metabolic process

 

AER366W

FLX1

Protein required for transport of FAD across the mitochondrial membrane

Regulation of translational elongation

 

AGR261W

RPS28B, RPS28A

Protein component of the small ribosomal subunit

 
  1. The corresponding S. cerevisiae homologs are indicated, as well as the predicted functions. The biological processes enriched (p < 0.01) in the up- and down-regulated gene clusters are also indicated.