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Table 2 Biological processes enriched (p < 0.01) in the co-expression clusters whose expression profiles varied differently in the DTT-treated vs . non-treated recombinant cells

From: Investigation of protein secretion and secretion stress in Ashbya gossypii

Cluster 1 Cluster 6
Ion transport Reproduction
Ribosomal large subunit biogenesis Response to pheromone
Glycosylation Ascospore wall assembly
Glycoprotein metabolic process mRNA splicing, via spliceosome
Macromolecule modification Conjugation
Cellular iron ion homeostasis M phase
Attachment of GPI anchor to protein Peptide transport
Lipoprotein metabolic process DNA recombination
Translational elongation External encapsulating structure organization
Sulfur amino acid transport Regulation of microtubule polymerization or depolymerization
Peptidyl-diphthamide biosynthetic process from peptidyl-histidine  
  DNA metabolic process
  Cell wall assembly
  RNA splicing
Cluster 2 Cluster 7
Reproduction Endocytosis
Organelle organization Response to biotic stimulus
Response to pheromone Positive regulation of homeostatic process
Growth Proteasome assembly
Multi-organism process Purine ribonucleoside catabolic process
Biological regulation Cell division
Transcription elongation from RNA polymerase II promoter NAD biosynthesis via nicotinamide riboside salvage pathway
Gene expression Amide biosynthetic process
Regulation of transcription during mitosis Response to singlet oxygen
Mitotic cell cycle Membrane invagination
Actin filament-based process Response to osmotic stress
Isoleucyl-tRNA aminoacylation Response to abiotic stimulus
Regulation of protein catabolic process  
Protein localization to organelle Cluster 9
Chromosome segregation Developmental process involved in reproduction
Small GTPase mediated signal transduction Vacuolar transport
Cellular localization Negative regulation of biological process
Regulation of localization Response to stimulus
Cell cycle Autophagy
DNA-dependent transcription elongation DNA-dependent transcription initiation
Proteolysis Cellular membrane fusion
Transcription from RNA polymerase II promoter Vacuolar protein processing
Macromolecule localization Post-translational protein modification
Cellular macromolecule biosynthetic process Cellular response to stress
Regulation of biological process Transcription initiation from RNA polymerase III promoter
Nucleus organization Macromolecule localization
Regulation of cell size Cytokinesis
Transmembrane transport DNA metabolic process
mRNA-binding (hnrnp) protein import into nucleus Vesicle-mediated transport
Nuclear pore organization Negative regulation of metabolic process
Nucleosome disassembly Vacuole organization
  Cell communication
  Meiotic mismatch repair
  Response to extracellular stimulus
  1. Clusters 1 and 6 were down-regulated by DTT, whereas clusters 2, 7 and 9 were up-regulated by DTT (Figure 4).