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Table 2 Biological processes enriched (p < 0.01) in the co-expression clusters whose expression profiles varied differently in the DTT-treated vs . non-treated recombinant cells

From: Investigation of protein secretion and secretion stress in Ashbya gossypii

Cluster 1

Cluster 6

Ion transport


Ribosomal large subunit biogenesis

Response to pheromone


Ascospore wall assembly

Glycoprotein metabolic process

mRNA splicing, via spliceosome

Macromolecule modification


Cellular iron ion homeostasis

M phase

Attachment of GPI anchor to protein

Peptide transport

Lipoprotein metabolic process

DNA recombination

Translational elongation

External encapsulating structure organization

Sulfur amino acid transport

Regulation of microtubule polymerization or depolymerization

Peptidyl-diphthamide biosynthetic process from peptidyl-histidine


DNA metabolic process


Cell wall assembly


RNA splicing

Cluster 2

Cluster 7



Organelle organization

Response to biotic stimulus

Response to pheromone

Positive regulation of homeostatic process


Proteasome assembly

Multi-organism process

Purine ribonucleoside catabolic process

Biological regulation

Cell division

Transcription elongation from RNA polymerase II promoter

NAD biosynthesis via nicotinamide riboside salvage pathway



Gene expression

Amide biosynthetic process

Regulation of transcription during mitosis

Response to singlet oxygen

Mitotic cell cycle

Membrane invagination

Actin filament-based process

Response to osmotic stress

Isoleucyl-tRNA aminoacylation

Response to abiotic stimulus

Regulation of protein catabolic process


Protein localization to organelle

Cluster 9

Chromosome segregation

Developmental process involved in reproduction

Small GTPase mediated signal transduction

Vacuolar transport

Cellular localization

Negative regulation of biological process

Regulation of localization

Response to stimulus

Cell cycle


DNA-dependent transcription elongation

DNA-dependent transcription initiation


Cellular membrane fusion

Transcription from RNA polymerase II promoter

Vacuolar protein processing

Macromolecule localization

Post-translational protein modification

Cellular macromolecule biosynthetic process

Cellular response to stress

Regulation of biological process

Transcription initiation from RNA polymerase III promoter

Nucleus organization

Macromolecule localization

Regulation of cell size


Transmembrane transport

DNA metabolic process

mRNA-binding (hnrnp) protein import into nucleus

Vesicle-mediated transport

Nuclear pore organization

Negative regulation of metabolic process

Nucleosome disassembly

Vacuole organization


Cell communication


Meiotic mismatch repair


Response to extracellular stimulus

  1. Clusters 1 and 6 were down-regulated by DTT, whereas clusters 2, 7 and 9 were up-regulated by DTT (Figure 4).