Investigation of protein secretion and secretion stress in Ashbya gossypii

Aguiar, Tatiana Q; Ribeiro, Orquídea; Arvas, Mikko; Wiebe, Marilyn G; Penttilä, Merja; Domingues, Lucília

doi:10.1186/1471-2164-15-1137

BMC Genomics

Table 4 Biological processes enriched (p < 0.001) in the gene clusters significantly up-regulated (fold change > 1.5 and p-value < 0.01) after 30 min, 1 h and 4 h of DTT treatment, in comparison with the time immediately before addition of DTT

From: Investigation of protein secretion and secretion stress in Ashbya gossypii

30 min	1 h	4 h
Spermine biosynthetic process	*Protein unfolding*	DNA dealkylation involved in DNA repair
Interspecies interaction between organisms	Bipolar cellular bud site selection
	Early endosome to golgi transport	Carbon utilization
S-adenosylmethionine transport	Membrane docking	Asexual reproduction
Traversing start control point of mitotic cell cycle	*Trehalose biosynthetic process*	Response to stimulus
	Phosphorus metabolic process	Negative regulation of transferase activity
Macromolecule metabolic process	Regulation of DNA repair
Glucose 1-phosphate metabolic process	Fructose transport	Early endosome to golgi transport
	Asymmetric protein localization	Cellular aldehyde metabolic process
Cis assembly of pre-catalytic spliceosome	Vesicle-mediated transport	NAD biosynthesis via nicotinamide riboside salvage pathway
	mRNA polyadenylation
Macromolecule catabolic process	Cellular localization	*Trehalose biosynthetic process*
*Protein unfolding*	Cell wall macromolecule catabolic process	*Protein unfolding*
Golgi localization		Nuclear mRNA 5′-splice site recognition
Leading strand elongation	Secretion
Cellular macromolecule metabolic process	Macromolecule localization	Asymmetric protein localization
	Cofactor transport	Secretion
Negative regulation of transcription from RNA polymerase II promoter during mitosis	Oligosaccharide metabolic process	Sodium ion transport
	Macromolecule catabolic process	Negative regulation of developmental process
	Positive regulation of lipid metabolic process
Proteolysis		Oligosaccharide metabolic process
Transcription initiation, DNA-dependent	Transcription from RNA polymerase II promoter	Tetrapyrrole catabolic process
		Intron homing
Stress-activated protein kinase signaling cascade	Negative regulation of catalytic activity	Negative regulation of catalytic activity
Negative regulation of transferase activity	Regulation of hydrolase activity	Regulation of hydrolase activity
	Regulation of transferase activity	Regulation of transferase activity
*Trehalose biosynthetic process*	Proteolysis	Glycerophospholipid catabolic process
	Regulation of response to stimulus
	Negative regulation of developmental process

GO terms highlighted in bold were overrepresented at two or all (bold italic) DTT exposure times.

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ISSN: 1471-2164

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