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Figure 6 | BMC Genomics

Figure 6

From: Evolutionarily emerged G tracts between the polypyrimidine tract and 3′ AG are splicing silencers enriched in genes involved in cancer

Figure 6

Significantly clustered functions of the REPA G tract-harboring genes. A. Shown is a bar graph of the –log (p-value) for the significance level of the functional comparison of 578 genes of the 627 3′SS (left most dark blue column in each functional category) with six random sets (2nd -7th column in each category) of 1319 human genes each. Brownish horizontal line: significance threshold of the functions/diseases of these genes above the background levels (random events) in the Ingenuity database. B. Heat map of the different cancers/biological functions with top log p values of enrichment. A scale bar with the color intensity/-log p value is to the upper right corner of the map. C. The WTX gene’s REPA G tract and alternative splicing as an example of genes involved in cancer whose alternative splicing (intron retention) causes a functional impact on gene function. The intron retention or splicing results in two isoforms of different lengths with different interaction with WT1 and effects on the latter’s transcriptional activity (Upper panel). The shorter isoform lacks the WT1-interaction domain at the COOH terminus (Lower panel).

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