Figure 5
From: Co-acting gene networks predict TRAIL responsiveness of tumour cells with high accuracy
The genes determining TRAIL-response-tend to be upstream regulators of components of cell death and cell survival signal transduction pathways. The figure shows direct (solid lines) and indirect interactions (dashed lines) amongst components of the cell death and survival signal transduction pathways. Genes from the 350 gene panel are coloured grey. Lines with arrowheads indicate functional interaction, such as regulation of expression or activity, while lines without arrowheads indicate protein-protein interactions.