Figure 3

Protein-protein interaction network for two diseases – neuroblastoma (A) and for ALS (B). Red nodes refer to OMIM-derived genes mutated in the cell line. Orange nodes refer to the OMIM-derived genes which are intact in the cell line. Dark green nodes represent genes coming from the network expansion, which are mutated in the cell line. Light green nodes represent genes coming from the network expansion, which are intact in the cell line. Nodes are scaled to the magnitude of their betweenness centralities. Blue edges show connections between pairs of nodes in which at least one was damaged in the cell line. For neuroblastoma, mutations in the central genes – NME1 and ALK contribute to the high BC-ratio. For the ALS network, mutations occur in genes with lower betweenness centrality which results in the lower BC-ratio.