Figure 5

Dopamine biosynthesis and degradation and the genes coding key enzymes. This metabolic pathway is a modified version of a figure from Meiser et al. [60]. In addition to the enzymes involved, the genes coding for those enzymes have been added using the HumanCyc [61]. The mutations in SH-SY5Y affecting enzyme-encoding genes have been annotated only if they were rare protein-altering SNVs or indels, CNVs, or SVs.