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Table 2 Network statistics and cell line scoring of the neurodegenrative diseases and neuroblastoma

From: Systems genomics evaluation of the SH-SY5Y neuroblastoma cell line as a model for Parkinson’s disease

Disease name

Nodes

Edges

Network centralization (Betweenness)

Cell line suitability based on centrality metrics

pBC-value

Total

Damaged

Intact

Degree

Closeness

BC-ratio

Flow BC

NB

63

15

48

192

.650

.362

.248

.591

.430

.010

AD

248

40

208

929

.405

.208

.161

.246

.215*

.040

PD

358

55

33

1862

.246

.156

.153

.186

.176*

.168

HD

63

10

53

153

.624

.183

.163

.146

.162

.472

ALS

178

22

156

371

.399

.116

.171

.084

.126*

.922

  1. Flow BC stands for flow betweenness centrality. The PBC-value refers to the network randomization test described in the Methods section. Flow Betwenness is defined for connected networks. If the entire network is not connected, Flow betweenness is computed for connected components. In the table the flow betweenness centrality of the largest connected component is given and marked by *. NB – Neuroblastoma; AD – Alzheimer’s disease; PD – Parkinson’s disease; HD – Huntington’s disease; ALS – Amyotrophic Lateral Sclerosis.