Predicted deleterious variant load in known SNHL genes derived from exome sequencing of SNHL probands. Black lines demarcate families. Purple bars indicate unaffected parents of probands in families. All included variants had a call quality greater than 20, and a frequency less than or equal to 15% in the 1000 genomes project, ESP, and Complete Genomics. The data represents a total of 134 variants in 46 genes (exons, splice sites, and miRNAs only).