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Table 4 Interesting genes significantly associated with SNHL

From: Exome sequencing and genome-wide copy number variant mapping reveal novel associations with sensorineural hereditary hearing loss

Gene Nexus NimbleScan
Case frequency Control frequency OR 95% CI FET p-value Case frequency Control frequency OR 95% CI FET p-value
NOMO1 41 13 4.20 9 4 2.46
2.14-8.21 0.74-8.16
1.88E-05 1.63E-01
GRAPL 68 38 2.62 43 27 1.95
1.61-4.26 1.13-3.36
1.26E-04 2.09E-02
PDXDC1 41 16 3.33 24 9 3.15
1.78-6.26 1.41-7.03
1.27E-04 5.17E-03
FCGR2C 45 23 2.51 14 9 1.70
1.43-4.42 0.71-4.06
1.54E-03 2.81E-01
NBPF4 18 6 3.45 1 1 1.05
1.33-8.96 0.07-17.00
9.96E-03 1.00E + 00
NPIP 44 28 1.92 41 17 3.12
1.12-3.30 1.68-5.79
2.21E-02 2.56E-04
FAM115A 45 29 1.91 23 16 1.6
1.12-3.25 0.81-3.18
2.34E-02 2.30E-01
OTOA 18 8 2.56 5 1 5.13
1.08-6.07
0.59-44.47
3.97E-02 1.15E-01
  1. Functionally interesting genes containing CNVs showing statistically significant associations with SNHL. The genes, case and control frequencies using both CNV calling algorithms, odds ratios, 95% confidence intervals, and p-values derived from Fisher’s Exact Tests are listed.