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Table 4 Interesting genes significantly associated with SNHL

From: Exome sequencing and genome-wide copy number variant mapping reveal novel associations with sensorineural hereditary hearing loss

Gene

Nexus

NimbleScan

Case frequency

Control frequency

OR 95% CI FET p-value

Case frequency

Control frequency

OR 95% CI FET p-value

NOMO1

41

13

4.20

9

4

2.46

2.14-8.21

0.74-8.16

1.88E-05

1.63E-01

GRAPL

68

38

2.62

43

27

1.95

1.61-4.26

1.13-3.36

1.26E-04

2.09E-02

PDXDC1

41

16

3.33

24

9

3.15

1.78-6.26

1.41-7.03

1.27E-04

5.17E-03

FCGR2C

45

23

2.51

14

9

1.70

1.43-4.42

0.71-4.06

1.54E-03

2.81E-01

NBPF4

18

6

3.45

1

1

1.05

1.33-8.96

0.07-17.00

9.96E-03

1.00E + 00

NPIP

44

28

1.92

41

17

3.12

1.12-3.30

1.68-5.79

2.21E-02

2.56E-04

FAM115A

45

29

1.91

23

16

1.6

1.12-3.25

0.81-3.18

2.34E-02

2.30E-01

OTOA

18

8

2.56

5

1

5.13

1.08-6.07

0.59-44.47

3.97E-02

1.15E-01

  1. Functionally interesting genes containing CNVs showing statistically significant associations with SNHL. The genes, case and control frequencies using both CNV calling algorithms, odds ratios, 95% confidence intervals, and p-values derived from Fisher’s Exact Tests are listed.
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BMC Genomics

ISSN: 1471-2164

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