Sequence search and analysis of gene products containing RNA recognition motifs in the human genome

BMC Genomics

Table 2 Domain architectures in isoforms

Domain architecture	Human protein	Domain architecture	Human protein
RRM_1,RRM_1,RRM_1	O60506	PWI, RRM_5,RRM_5	Q5T8P6
RRM_1,RRM_1	O60506-2	PWI, RRM_5,RRM_5	Q5T8P6-2
RRM_1,RRM_1,RRM_1	O60506-3	PWI, RRM_5,RRM_5	Q5T8P6-3
RRM_1,RRM_1	O60506-4	RRM_5,RRM_5	Q5T8P6-4
RRM_1,RRM_1,RRM_1	O60506-5	RRM_5,RRM_5	Q5T8P6-5
La, RRM_1,RRM_3	Q4G0J3	RRM_1,RRM_1	Q86SG3
RRM_3	Q4G0J3-2	RRM_1	Q86SG3-2
RRM_5	O95628	RRM_1,RRM_1,RRM_1,RRM_1	Q8IUH3
RRM_5	O95628-2	RRM_1,RRM_1,RRM_1	Q8IUH3-2
RRM_5	O95628-3	RRM_1,RRM_1,RRM_1,RRM_1	Q8IUH3-3
zf-C3HC4_3,RRM_5	O95628-4	RRM_1,RRM_1,RRM_1	Q8N6W0
RRM_5	O95628-5	RRM_1,RRM_1	Q8N6W0-2
RRM_5	O95628-6	zf-CCCH,zf-CCCH	Q8WU68
zf-C3HC4_3,RRM_5	O95628-7	zf-CCCH	Q8WU68-2
zf-C3HC4_3,RRM_5	O95628-8	zf-CCCH,zf-CCCH	Q8WU68-3
RRM_6,RRM_6	P31942	RRM_5,RRM_5,RRM_5	Q8WVV9
RRM_6,RRM_6	P31942-2	RRM_5,RRM_5	Q8WVV9-2
RRM_6,RRM_6	P31942-3	RRM_5,RRM_5	Q8WVV9-3
RRM_6	P31942-4	RRM_5,RRM_5,RRM_5	Q8WVV9-4
RRM_6	P31942-5	RRM_1,RRM_1,RRM_1	Q96J87
RRM_6	P31942-6	RRM_1,RRM_1	Q96J87-2
RRM_1,RRM_1,RRM_1	Q9P2K5	RRM_1,RRM_1,RRM_1	Q96J87-3
RRM_1,RRM_1,RRM_1	Q9P2K5-2	RRM_1,RRM_1	Q96J87-4
RRM_1	Q9P2K5-3

928 RRM-containing gene products were studied for their co-existing domains. We observed that in 13 gene products where isoforms are reported the domain architectures are different. This implies may be during the alternative splicing event full domains are also spliced out.

ISSN: 1471-2164