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Figure 4 | BMC Genomics

Figure 4

From: Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates

Figure 4

Differential cytokine stimulated gene expression in human airway epithelial cells infected with distinct MERS-CoVs. A. Venn diagram shows the number of genes which were DE after infection in any one virus or time point and their overlap within four sets of different cytokine stimulation. Whereas IFN-α, IFN-γ and IL-1α show a large number of specific genes, TNF stimulated DE genes share many genes with other cytokines B. Heatmap of 149 DE genes following either MERS-CoV SA 1 or MERS-CoV Eng 1 infection (MOI 5) that show strong contrasts at 18 and 24 hpi. The black bars on the left of the heatmap indicate whether genes were also DE after cytokine treatments (IFN-α, IFN-γ, IL-1α, TNF-α) in the same cell line system as the infection.

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