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Table 2 Canonical Pathways enriched in human airway cells infected with MERS-CoV

From: Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates

MERS virus Canonical pathwaya -log p-val molbmolc
MERS-CoV Eng 1 vs MERS-CoV SA 1 Role of Macrophages, Fibroblasts and Endothelial Cells in RA 5.80 94/342
(4861 DEG) Tumoricidal Function of Hepatic Natural Killer Cells 3.77 13/27
  VDR/RXR Activation 3.66 29/88
  Wnt/β-catenin Signaling 3.63 53/175
  G-Protein Coupled Receptor Signaling 3.60 74/276
Cluster 2 Wnt/β-catenin Signaling 5.40 23/175
(1108 DEG) NGF Signaling 5.11 17/122
  Epithelial Adherens Junction Signaling 4.89 20/154
  PPARα/RXRα Activation 4.68 22/200
  ILK Signaling 4.27 22/205
Cluster 4 Glutathione-mediated Detoxification 5.51 5/45
(194 DEG) Antigen Presentation Pathway 4.89 5/42
  Ascorbate Recycling (Cytosolic) 3.69 2/13
  Glutathione Redox Reactions I 3.46 2/24
  Aryl Hydrocarbon Receptor Signaling 2.95 6/171
Cluster 10 Notch Signaling 3.17 6/43
(648 DEG) 1D-myo-inositol Hexakisphosphate Biosynthesis II (Mammalian) 1.79 3/28
  D-myo-inositol (1,3,4)-trisphosphate Biosynthesis 1.79 3/25
  Ephrin B Signaling 1.71 6/82
  Tumoricidal Function of Hepatic Natural Killer Cells 1.52 3/27
Cluster 11 Interferon Signaling 2.40 2/36
(61 DEG) Phenylethylamine Degradation I 1.96 1/11
  IL-17A Signaling in Airway Cells 1.87 2/76
  BMP signaling pathway 1.74 2/86
  TGF-β Signaling 1.66 2/94
Cluster 12 (576 DEG) Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17 F 3.24 4/18
  Role of Cytokines in Mediating Communication between Immune Cells 2.87 6/54
  Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17 F 2.82 4/23
  G-Protein Coupled Receptor Signaling 2.71 14/276
  Agranulocyte Adhesion and Diapedesis 2.55 11/192
  1. Ingenuity Pathway Analysis was used to determine significant Canonical Pathways for the entire heatmap of contrasting genes (MERS-CoV Eng 1 vs MERS-CoV SA 1) and for individual Clusters 2, 4, 10, 11, and 12 that had the most contrasting patterns of gene expression at 18 and 24 hpi.
  2. aRA: Rheumatoid Arthritis.
  3. bNumber of molecules differentially expressed in the canonical pathway.
  4. cTotal number of molecules in the annotated canonical pathway.