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Table 2 Canonical Pathways enriched in human airway cells infected with MERS-CoV

From: Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates

MERS virus

Canonical pathwaya

-log p-val

molbmolc

MERS-CoV Eng 1 vs MERS-CoV SA 1

Role of Macrophages, Fibroblasts and Endothelial Cells in RA

5.80

94/342

(4861 DEG)

Tumoricidal Function of Hepatic Natural Killer Cells

3.77

13/27

 

VDR/RXR Activation

3.66

29/88

 

Wnt/β-catenin Signaling

3.63

53/175

 

G-Protein Coupled Receptor Signaling

3.60

74/276

Cluster 2

Wnt/β-catenin Signaling

5.40

23/175

(1108 DEG)

NGF Signaling

5.11

17/122

 

Epithelial Adherens Junction Signaling

4.89

20/154

 

PPARα/RXRα Activation

4.68

22/200

 

ILK Signaling

4.27

22/205

Cluster 4

Glutathione-mediated Detoxification

5.51

5/45

(194 DEG)

Antigen Presentation Pathway

4.89

5/42

 

Ascorbate Recycling (Cytosolic)

3.69

2/13

 

Glutathione Redox Reactions I

3.46

2/24

 

Aryl Hydrocarbon Receptor Signaling

2.95

6/171

Cluster 10

Notch Signaling

3.17

6/43

(648 DEG)

1D-myo-inositol Hexakisphosphate Biosynthesis II (Mammalian)

1.79

3/28

 

D-myo-inositol (1,3,4)-trisphosphate Biosynthesis

1.79

3/25

 

Ephrin B Signaling

1.71

6/82

 

Tumoricidal Function of Hepatic Natural Killer Cells

1.52

3/27

Cluster 11

Interferon Signaling

2.40

2/36

(61 DEG)

Phenylethylamine Degradation I

1.96

1/11

 

IL-17A Signaling in Airway Cells

1.87

2/76

 

BMP signaling pathway

1.74

2/86

 

TGF-β Signaling

1.66

2/94

Cluster 12 (576 DEG)

Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17 F

3.24

4/18

 

Role of Cytokines in Mediating Communication between Immune Cells

2.87

6/54

 

Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17 F

2.82

4/23

 

G-Protein Coupled Receptor Signaling

2.71

14/276

 

Agranulocyte Adhesion and Diapedesis

2.55

11/192

  1. Ingenuity Pathway Analysis was used to determine significant Canonical Pathways for the entire heatmap of contrasting genes (MERS-CoV Eng 1 vs MERS-CoV SA 1) and for individual Clusters 2, 4, 10, 11, and 12 that had the most contrasting patterns of gene expression at 18 and 24 hpi.
  2. aRA: Rheumatoid Arthritis.
  3. bNumber of molecules differentially expressed in the canonical pathway.
  4. cTotal number of molecules in the annotated canonical pathway.
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BMC Genomics

ISSN: 1471-2164

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