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Table 1 Lists of protein kinases whose inhibition leads to low and high Mitotic Index

From: Integrative analysis of high-throughput RNAi screen data identifies the FER and CRKL tyrosine kinases as new regulators of the mitogenic ERK-dependent pathways in transformed cells

Low mitotic index

High mitotic index

Symbol

Gene description

Symbol

Gene description

ACVR1B

Activin A receptor, type IB

AKT3

V-akt murine thymoma viral oncogene homolog 3

ADRBK2

Adrenergic, beta, receptor kinase 2

ALS2CR2

Amyotrophic lateral sclerosis 2 (juvenile) chromosome region

AK2

Adenylate kinase 2

BUB1

BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)

ALPK2

Alpha-kinase 2

CAMK1

Calcium/calmodulin-dependent protein kinase I

ARAF

V-raf murine sarcoma 3611 viral oncogene homolog

CDC2L1

Cell division cycle 2-like protein kinase 1

AURKB

Aurora kinase B

CDC7

Cell division cycle 7 homolog (S. cerevisiae)

BRD4

Bromodomain containing 4

CDKL4

Cyclin-dependent kinase-like 4

BTK

Bruton agammaglobulinemia tyrosine kinase

CHKB

choline kinase beta

CAMK1D

Calcium/calmodulin-dependent protein kinase ID

CIT

Citron (rho-interacting, serine/threonine kinase 21)

CDC42BPG

CDC42 binding protein kinase gamma (DMPK-like)

DAK

Dihydroxyacetone kinase 2 homolog (S. cerevisiae)

CDKL3

Cyclin-dependent kinase-like 3

DDR2

Discoidin domain receptor family, member 2

CLK2

CDC-like kinase 2

DGKB

Diacylglycerol kinase, beta 90 kDa

CRKL

V-crk sarcoma virus CT10 oncogene homolog (avian)-like

EIF2AK2

Eukaryotic translation initiation factor 2-alpha kinase 2

DCAMKL1

Doublecortin-like and CAM kinase-like 1

ETNK2

Ethanolamine kinase 2

DGKE

Diacylglycerol kinase, epsilon 64 kDa

FGFR1

Fibroblast growth factor receptor 1

DMPK

Dystrophia myotonica-protein kinase

FGFR4

Fibroblast growth factor receptor 4

FER

Fer (fps/fes related) tyrosine kinase

GRK1

G protein-coupled receptor kinase 1

FGFR3

Fibroblast growth factor receptor 3

GRK5

G protein-coupled receptor kinase 5

GSK3A

Glycogen synthase kinase 3 alpha

HIPK2

Homeodomain interacting protein kinase 2

IRAK3

Interleukin-1 receptor-associated kinase 3

IGF1R

Insulin-like growth factor 1 receptor

LMTK2

Lemur tyrosine kinase 2

IHPK3

Inositol hexaphosphate kinase 3

LRRK1

Leucine-rich repeat kinase 1

LATS2

LATS, large tumor suppressor, homolog 2 (Drosophila)

MAPKAPK3

Mitogen-activated protein kinase-activated protein kinase 3

MAP3K14

Mitogen-activated protein kinase kinase kinase 14

MAPKAPK5

Mitogen-activated protein kinase-activated protein kinase 5

MAP3K6

Mitogen-activated protein kinase kinase kinase 6

MARK1

MAP/microtubule affinity-regulating kinase 1

MAPK6

Mitogen-activated protein kinase 6

MPP3

Membrane protein, palmitoylated 3

NAGK

N-acetylglucosamine kinase

PDIK1L

PDLIM1 interacting kinase 1 like

NEK10

NIMA (never in mitosis gene a)- related kinase 10

PDK2

Pyruvate dehydrogenase kinase, isozyme 2

PDZD2

PDZ domain containing 2

PGK2

Phosphoglycerate kinase 2

PGK1

Phosphoglycerate kinase 1

PHKA1

Phosphorylase kinase, alpha 1 (muscle)

PIM3

Pim-3 oncogene

PHKG2

Phosphorylase kinase, gamma 2 (testis)

PKMYT1

Protein kinase, membrane associated tyrosine/threonine 1

PIK3CB

Phosphoinositide-3-kinase, catalytic, beta polypeptide

PLK1

Polo-like kinase 1 (Drosophila)

PRKAA2

Protein kinase, AMP-activated, alpha 2 catalytic subunit

PLK2

Polo-like kinase 2 (Drosophila)

PRKCE

Protein kinase C, epsilon

PMVK

Phosphomevalonate kinase

RIPK2

Receptor-interacting serine-threonine kinase 2

PRKAR2B

Protein kinase, cAMP-dependent, regulatory, type II, beta

RIPK4

Receptor-interacting serine-threonine kinase 4

PRKCB1

Protein kinase C, beta 1

SPHK2

sphingosine kinase 2

PRKD3

Protein kinase D3

STC1

Stanniocalcin 1

PRKDC

Protein kinase, DNA-activated, catalytic polypeptide

STK40

Serine/threonine kinase 40

PRPS1L1

Phosphoribosyl pyrophosphate synthetase 1-like 1

TNK1

Tyrosine kinase, non-receptor, 1

PSKH1

Protein serine kinase H1

ULK2

Unc-51-like kinase 2 (C. elegans)

PXK

PX domain containing serine/threonine kinase

  

SNRK

SNF related kinase

  

SRMS

Src-related kinase

  

STK17B

Serine/threonine kinase 17b

  

STK36

Serine/threonine kinase 36, fused homolog (Drosophila)

  

TNIK

TRAF2 and NCK interacting kinase

  

TPK1

Thiamin pyrophosphokinase 1

  

TRPM7

Transient receptor potential cation channel, subfamily M, member 7

  

VRK3

Vaccinia related kinase 3

  

WNK3

WNK lysine deficient protein kinase 3