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Table 1 Lists of protein kinases whose inhibition leads to low and high Mitotic Index

From: Integrative analysis of high-throughput RNAi screen data identifies the FER and CRKL tyrosine kinases as new regulators of the mitogenic ERK-dependent pathways in transformed cells

Low mitotic index High mitotic index
Symbol Gene description Symbol Gene description
ACVR1B Activin A receptor, type IB AKT3 V-akt murine thymoma viral oncogene homolog 3
ADRBK2 Adrenergic, beta, receptor kinase 2 ALS2CR2 Amyotrophic lateral sclerosis 2 (juvenile) chromosome region
AK2 Adenylate kinase 2 BUB1 BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)
ALPK2 Alpha-kinase 2 CAMK1 Calcium/calmodulin-dependent protein kinase I
ARAF V-raf murine sarcoma 3611 viral oncogene homolog CDC2L1 Cell division cycle 2-like protein kinase 1
AURKB Aurora kinase B CDC7 Cell division cycle 7 homolog (S. cerevisiae)
BRD4 Bromodomain containing 4 CDKL4 Cyclin-dependent kinase-like 4
BTK Bruton agammaglobulinemia tyrosine kinase CHKB choline kinase beta
CAMK1D Calcium/calmodulin-dependent protein kinase ID CIT Citron (rho-interacting, serine/threonine kinase 21)
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like) DAK Dihydroxyacetone kinase 2 homolog (S. cerevisiae)
CDKL3 Cyclin-dependent kinase-like 3 DDR2 Discoidin domain receptor family, member 2
CLK2 CDC-like kinase 2 DGKB Diacylglycerol kinase, beta 90 kDa
CRKL V-crk sarcoma virus CT10 oncogene homolog (avian)-like EIF2AK2 Eukaryotic translation initiation factor 2-alpha kinase 2
DCAMKL1 Doublecortin-like and CAM kinase-like 1 ETNK2 Ethanolamine kinase 2
DGKE Diacylglycerol kinase, epsilon 64 kDa FGFR1 Fibroblast growth factor receptor 1
DMPK Dystrophia myotonica-protein kinase FGFR4 Fibroblast growth factor receptor 4
FER Fer (fps/fes related) tyrosine kinase GRK1 G protein-coupled receptor kinase 1
FGFR3 Fibroblast growth factor receptor 3 GRK5 G protein-coupled receptor kinase 5
GSK3A Glycogen synthase kinase 3 alpha HIPK2 Homeodomain interacting protein kinase 2
IRAK3 Interleukin-1 receptor-associated kinase 3 IGF1R Insulin-like growth factor 1 receptor
LMTK2 Lemur tyrosine kinase 2 IHPK3 Inositol hexaphosphate kinase 3
LRRK1 Leucine-rich repeat kinase 1 LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)
MAPKAPK3 Mitogen-activated protein kinase-activated protein kinase 3 MAP3K14 Mitogen-activated protein kinase kinase kinase 14
MAPKAPK5 Mitogen-activated protein kinase-activated protein kinase 5 MAP3K6 Mitogen-activated protein kinase kinase kinase 6
MARK1 MAP/microtubule affinity-regulating kinase 1 MAPK6 Mitogen-activated protein kinase 6
MPP3 Membrane protein, palmitoylated 3 NAGK N-acetylglucosamine kinase
PDIK1L PDLIM1 interacting kinase 1 like NEK10 NIMA (never in mitosis gene a)- related kinase 10
PDK2 Pyruvate dehydrogenase kinase, isozyme 2 PDZD2 PDZ domain containing 2
PGK2 Phosphoglycerate kinase 2 PGK1 Phosphoglycerate kinase 1
PHKA1 Phosphorylase kinase, alpha 1 (muscle) PIM3 Pim-3 oncogene
PHKG2 Phosphorylase kinase, gamma 2 (testis) PKMYT1 Protein kinase, membrane associated tyrosine/threonine 1
PIK3CB Phosphoinositide-3-kinase, catalytic, beta polypeptide PLK1 Polo-like kinase 1 (Drosophila)
PRKAA2 Protein kinase, AMP-activated, alpha 2 catalytic subunit PLK2 Polo-like kinase 2 (Drosophila)
PRKCE Protein kinase C, epsilon PMVK Phosphomevalonate kinase
RIPK2 Receptor-interacting serine-threonine kinase 2 PRKAR2B Protein kinase, cAMP-dependent, regulatory, type II, beta
RIPK4 Receptor-interacting serine-threonine kinase 4 PRKCB1 Protein kinase C, beta 1
SPHK2 sphingosine kinase 2 PRKD3 Protein kinase D3
STC1 Stanniocalcin 1 PRKDC Protein kinase, DNA-activated, catalytic polypeptide
STK40 Serine/threonine kinase 40 PRPS1L1 Phosphoribosyl pyrophosphate synthetase 1-like 1
TNK1 Tyrosine kinase, non-receptor, 1 PSKH1 Protein serine kinase H1
ULK2 Unc-51-like kinase 2 (C. elegans) PXK PX domain containing serine/threonine kinase
   SNRK SNF related kinase
   SRMS Src-related kinase
   STK17B Serine/threonine kinase 17b
   STK36 Serine/threonine kinase 36, fused homolog (Drosophila)
   TNIK TRAF2 and NCK interacting kinase
   TPK1 Thiamin pyrophosphokinase 1
   TRPM7 Transient receptor potential cation channel, subfamily M, member 7
   VRK3 Vaccinia related kinase 3
   WNK3 WNK lysine deficient protein kinase 3
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BMC Genomics

ISSN: 1471-2164

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