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Table 2 False non-synonymous SNVs called by the different strategies, with reads generated from both exonic and non-exonic regions

From: Are special read alignment strategies necessary and cost-effective when handling sequencing reads from patient-derived tumor xenografts?

Strategy False positive non-synonymous SNVs False negative non-synonymous SNVs
No contamination 0 228
Direct 47 251
Filtering 0 265
Combined 3 70
  1. False non-synonymous SNVs called by the different strategies, and true non-synonymous SNVs missed by them, under the mH.len100.eL setting with 1:1 human-mouse mixing ratio and reads generated from both exonic and non-exonic regions of human chromosome 14 and mouse chromosome 12.
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BMC Genomics

ISSN: 1471-2164

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