Skip to main content

Table 3 False non-synonymous SNVs called by the different strategies, with reads generated from only exonic regions

From: Are special read alignment strategies necessary and cost-effective when handling sequencing reads from patient-derived tumor xenografts?

Strategy

False positive non-synonymous SNVs

False negative non-synonymous SNVs

No contamination

5

159,014

Direct

551

160,374

Filtering

5

159,989

Combined

16

150,988

  1. False non-synonymous SNVs called by the different strategies, and true non-synonymous SNVs missed by them, under the mH.len100.eL setting with 1:1 human-mouse mixing ratio and reads generated from exonic regions only of human chromosome 14 and mouse chromosome 12.