Distinct gene signatures in aortic tissue from ApoE-/-mice exposed to pathogens or Western diet

BMC Genomics

Table 4 Gene set enrichment analysis

Rank	Gene set
1	KEGG hypertrophic cardiomyopathy
2	KEGG dilated cardiomyopathy
3	Reactome muscle contraction
4	Reactome striated muscle contraction
5	Muscle development
21	Skeletal muscle development
6	Actin cytoskeleton
8	Structural molecule activity
7	Structural constituent of muscle
9	Regulation of multicellular organismal process
12	Regulation of heart contraction
25	Regulation of muscle contraction
10	KEGG cardiac muscle contraction
11	Cytoskeletal protein binding
23	Actin binding
13	KEGG arrhythmogenic right ventricular cardiomyopathy ARVC
14	Contractile fiber
15	Contractile fiber part
19	Myofibril
16	Heart development
20	Gated channel activity
17	Voltage gated channel activity
18	Voltage gated cation channel activity
22	Cation channel activity
24	Cytoskeletal part

Negative enrichment: chronic C. pneumoniae-treated group vs. chronic control group.
The top 25 C. pneumoniae gene sets whose member genes are predominantly downregulated with respect to the chronic control group. Column 1 indicates the rank of the gene set based on Normalized Enrichment Score (NES). Column 2 lists the gene set name (bold) as provided by MSigDB. Gene set names and ranks that are not in bold are gene sets that are redundant or partially redundant and included within larger bolded gene sets. The NES ranged from -2.79 (for KEGG Hypertrophic Cardiomyopathy, the top ranked gene set) to -2.23 (Regulation of Muscle Contraction, the 25th-ranked gene set). FDR q < 1 × 10^-30.

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