Distinct gene signatures in aortic tissue from ApoE-/-mice exposed to pathogens or Western diet

BMC Genomics

Table 6 Gene set enrichment analysis

Rank	Gene set
1	G protein coupled receptor activity
6	Rhodopsin like receptor activity
14	Peptide receptor activity
2	Apical junction complex
3	Apicolateral plasma membrane
4	Neurotransmitter binding
5	Neuropeptide receptor activity
7	Neurotransmitter receptor activity
10	Neuropeptide binding
9	KEGG neuroactive ligand receptor interaction
11	Reactome amine ligand binding receptors
24	Amine receptor activity
12	Intercellular junction
8	Tight junction
13	Structural constituent of muscle
15	Calcium channel activity
16	Feeding behavior
18	Voltage gated channel activity
17	Voltage gated potassium channel activity
20	Voltage gated cation channel activity
19	KEGG basal cell carcinoma
21	Contractile fiber
22	Anion transmembrane transporter activity
23	Reactome tight junction interactions
25	Digestion

Negative enrichment: Western diet group vs. chronic control group.
The top 25 Western diet gene sets whose member genes are predominantly downregulated with respect to the chronic control group. Column 1 indicates the rank of the gene set based on Normalized Enrichment Score (NES). Column 2 lists the gene set name (bold) as provided by MSigDB. Gene set names and ranks that are not in bold are gene sets that are redundant or partially redundant and included within larger bolded gene sets. The NES ranged from -3.43 (for G Protein Coupled Receptor Activity, the top ranked gene set) to -1.92 (Digestion, the 25th-ranked gene set). FDR q range: 0 – 0.015.

ISSN: 1471-2164