Figure 5

Shapes of key promoters of the three genes. Promoter shapes were drawn for the key promoters of the three genes (panels a to j, as labeled) based on the location of the first nucleotide in all tissues in mouse (panels a to e) and humans (panels f to j). Shape conservation is seen across the two species in all promoters except pB of Foxg1 in mouse and p2 of FOXG1 in humans. Despite the closeness in location and high correlation between p1 and p2 of CDKL5, we find variation in their shapes suggesting differential regulation in both species.