Figure 8

Statistical significance of the extra information provided by an mRNA in our MTBs in explaining the relationship between a miRNA and another mRNA in the same MTB. The p-values were computed by comparing the fractions of d(R,T1,T2) (see Materials and methods) more negative than the threshold t of the (R,T1,T2) combinations within MTBs, as compared to a background consisting of (R,T1,T2) combinations where R comes from the same MTBs but T1 and T2 do not. In the figure, 1E-16 represents the smallest p-value that could be outputted by our program.