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Table 1 Significantly different genes identified from H. parasuis between clinical and non-clinical isolates using DAPC

From: The use of genome wide association methods to investigate pathogenicity, population structure and serovar in Haemophilus parasuis

Predicted function of gene

Number of genes

Existing virulence factor for H. parasuis

Adhesins, yadA family

4

Yes

antirepressor

1

 

Aspartokinase lysC

1

 

ATPdependent RNA helicase hrpA

1

 

cytolethal distending toxin protein A

2

Yes

cytolethal distending toxin protein B

1

Yes

DNA binding domain, excisionase family

1

 

enoyl-CoA hydratase/carnithine racemase-like protein

1

 

Ferric hydroxamate uptake

1

 

Gene 25like lysozyme

1

 

glycerol uptake facilitator protein

1

 

Modification methylase hpaII

1

 

MuF Haemophilus phage SuMu

1

 

N-acetylmuramoyl-L-alanine amidase

1

 

phage tail sheath family protein

1

 

putative 3-phenylpropionic acid transporter

1

 

Putative NADH flavin reductase/short chain dehydrogenase

1

 

putative outer membrane usher protein htrE

1

 

putative serine protease

1

Yes

tonB-dependent receptor plug domain protein

1

Yes

Trans-2,3-dihydro-3-hydroxyanthranilate isomerase

1

 

Transcriptional activator prtR

1

 

transposase

1

 

UDP3O [3hydroxymyristoyl] glucosamine N-acyltransferase

1

 

unknown function

19

 

Xylose import ATPbinding protein xylG

1

 
  1. All genes were identified as significant using generalised linear modelling of different DAPC iterations using between 60-90% of the principal components (p < 0.05). The phenotypic data used in the model was whether isolates were clinical or non-clinical compared to the presence or absence of the genes.