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Table 1 Description of the datasets used in this study and the statistical evaluation of age-associated probes

From: Major aging-associated RNA expressions change at two distinct age-positions

Tissue

Chronological datasets

Permuted datasets (N=100)

Nr. samples

Age range

GT p-value *

Age-regulated **

Age-regulated mean ± SE**

[Ps>Cs/Ps<Cs]^

VL muscles

29

35-89

0.015

4101

2991 ± 86.1

7/93 [0.07]

Brain cortex

30

26-106

0.004

2339

677 ± 52.2

3/97 [0.03]

Kidney cortex

72

27-92

0.002

2397

1136 ± 77.2

11/89 [0.12]

Kidney medulla

61

29-92

0.205

1474

1090 ± 70.0

24/76 [0.31]

  1. Table shows the four datasets used in this study in chronological order and permuted samples. The number of samples and the age range (in years) are indicated.
  2. * The p-value determined with the globaltest (GT).
  3. ** The number of age-regulated probes (p-value < 0.05) was determined using a quadratic regression model and no age-association as null hypothesis. In the permuted datasets, the mean and the standard error (SE) from 100 permutations per dataset were calculated.
  4. ^The ratio between permuted samples (Ps) with a higher to lower number of significant probes, compared with chronologically ordered samples (Cs).
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BMC Genomics

ISSN: 1471-2164

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