Protein sub-networks identified by the miPALM algorithm and visualized using Cytoscape. Strength of the interaction between two proteins is depicted by line width. The color of each node represents the negative log p-value from the t-test (see color bar insert) between smokers and non-smokers after correction for multiple comparisons (-log P’). Sub-network (a) and (b) consists of 5 proteins (p < 0.002) and 6 proteins (p < 0.008) respectively, enriched for immune function based on the BiNGO analysis. Sub-network (c) consists of 16 proteins (p < 0.05) enriched for the JAK-STAT signaling pathway based on the BiNGO analysis. Sub-network (d) consists of 17 proteins (p < 0.03) enriched for coagulation based on the BiNGO analysis.