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Table 3 The top 30 differentially regulated gene ontology pathways from the GoMiner analysis

From: The effect of smoking on DNA methylation of peripheral blood mononuclear cells from African American women

   Genes   
GO category Category name Total Changed Log10 p-value FDR
GO:0004012 Phospholipid-translocating ATPase activity 15 6 -5.35 0.00
GO:0005548 Phospholipid transporter activity 29 7 -4.51 0.04
GO:0042954 Lipoprotein transporter activity 3 3   
GO:0015914 Phospholipid transport 33 7 -4.12 0.09
GO:0010876 Lipid localization 188 16 -3.36 0.37
GO:0016043 Cellular component organization 3231 136 -3.26 0.36
GO:0042623 ATPase activity coupled 276 20 -3.14 0.45
GO:0016887 ATPase activity 343 23 -3.06 0.44
GO:0003708 Retinoic acid receptor activity 7 3 -2.97 0.49
GO:0006869 Lipid transport 167 14 -2.95 0.45
GO:0045892 Negative regulation of transcription DNA-dependent 439 27 -2.92 0.42
GO:0005319 Lipid transporter activity 66 8 -2.89 0.39
GO:0051253 Negative regulation of RNA metabolic process 446 27 -2.82 0.42
GO:0071840 Cellular component organization or biogenesis 3341 137 -2.82 0.39
GO:0016817 Hydrolase activity acting on acid anhydrides 777 41 -2.80 0.38
GO:0042491 Auditory receptor cell differentiation 17 4 -2.73 0.42
GO:0042626 ATPase activity coupled to transmembrane movement of substances 103 10 -2.72 0.40
GO:0043492 ATPase activity coupled to movement of substances 104 10 -2.69 0.39
GO:0016820 Hydrolase activity acting on acid anhydrides catalyzing transmembrane movement of substances 105 10 -2.66 0.38
GO:0003727 Single-stranded RNA binding 29 5 -2.65 0.35
GO:0043954 Cellular component maintenance 29 5 -2.65 0.35
GO:0045668 Negative regulation of osteoblast differentiation 18 4 -2.63 0.35
GO:0016462 Pyrophosphatase activity 770 40 -2.62 0.34
GO:0005112 Notch binding 9 3 -2.61 0.35
GO:0016818 Hydrolase activity acting on acid anhydrides in phosphorus-containing anhydrides 773 40 -2.59 0.35
GO:0065007 Biological regulation 7226 267 -2.54 0.36
GO:0032504 Multicellular organism reproduction 514 29 -2.53 0.35
GO:0048609 Multicellular organismal reproductive process 514 29 -2.53 0.35
GO:0032502 Developmental process 3571 143 -2.53 0.34
GO:0004032 Aldehyde reductase activity 3 2