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Table 3 The top 30 differentially regulated gene ontology pathways from the GoMiner analysis

From: The effect of smoking on DNA methylation of peripheral blood mononuclear cells from African American women

  

Genes

  

GO category

Category name

Total

Changed

Log10 p-value

FDR

GO:0004012

Phospholipid-translocating ATPase activity

15

6

-5.35

0.00

GO:0005548

Phospholipid transporter activity

29

7

-4.51

0.04

GO:0042954

Lipoprotein transporter activity

3

3

  

GO:0015914

Phospholipid transport

33

7

-4.12

0.09

GO:0010876

Lipid localization

188

16

-3.36

0.37

GO:0016043

Cellular component organization

3231

136

-3.26

0.36

GO:0042623

ATPase activity coupled

276

20

-3.14

0.45

GO:0016887

ATPase activity

343

23

-3.06

0.44

GO:0003708

Retinoic acid receptor activity

7

3

-2.97

0.49

GO:0006869

Lipid transport

167

14

-2.95

0.45

GO:0045892

Negative regulation of transcription DNA-dependent

439

27

-2.92

0.42

GO:0005319

Lipid transporter activity

66

8

-2.89

0.39

GO:0051253

Negative regulation of RNA metabolic process

446

27

-2.82

0.42

GO:0071840

Cellular component organization or biogenesis

3341

137

-2.82

0.39

GO:0016817

Hydrolase activity acting on acid anhydrides

777

41

-2.80

0.38

GO:0042491

Auditory receptor cell differentiation

17

4

-2.73

0.42

GO:0042626

ATPase activity coupled to transmembrane movement of substances

103

10

-2.72

0.40

GO:0043492

ATPase activity coupled to movement of substances

104

10

-2.69

0.39

GO:0016820

Hydrolase activity acting on acid anhydrides catalyzing transmembrane movement of substances

105

10

-2.66

0.38

GO:0003727

Single-stranded RNA binding

29

5

-2.65

0.35

GO:0043954

Cellular component maintenance

29

5

-2.65

0.35

GO:0045668

Negative regulation of osteoblast differentiation

18

4

-2.63

0.35

GO:0016462

Pyrophosphatase activity

770

40

-2.62

0.34

GO:0005112

Notch binding

9

3

-2.61

0.35

GO:0016818

Hydrolase activity acting on acid anhydrides in phosphorus-containing anhydrides

773

40

-2.59

0.35

GO:0065007

Biological regulation

7226

267

-2.54

0.36

GO:0032504

Multicellular organism reproduction

514

29

-2.53

0.35

GO:0048609

Multicellular organismal reproductive process

514

29

-2.53

0.35

GO:0032502

Developmental process

3571

143

-2.53

0.34

GO:0004032

Aldehyde reductase activity

3

2

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