Inhibition of adenylate cyclases is more toxic to FH-deficient than to FH-expressing HLRCC cells. (A) Colony formation in UOK262 versus UOK262pFH after the infection with the indicated shRNA. (B) Gene expression level of adenylate cyclase genes in UOK262 and UOK262pFH. (C) Colony formation following treatment of UOK262 and UOK262pFH cells with indicated concentrations of the adenylate cyclases inhibitor MDL-12,330A. (D) Representative images of a colony survival assay of UOK262 and UOK262pFH after the treatment with 1 μM MDL-12,330A for 7 days.