Figure 5

Focus on detoxification: cytochrome P450s. Clustering analyses of transcription level variations (upper panel) and differential SNPs (lower panel) affecting cytochrome P450 monooxygenases (CYP genes). Clustering was performed on all transcripts showing significant transcription level variations or differential SNPs within their coding region in any strain. The green-red color scale indicates transcription level variations as compared to the susceptible strain. Stars indicate a significant differential transcription. Blue-yellow color scale indicates allele frequency variations as compared to the susceptible strain. Amino acid position, amino-acid change, transcript number and gene names are indicated. Non-synonymous variations according to genome annotation are underlined. SNPs falling within P450 Substrate Recognition Sites (SRS) are indicated. Names ending with a question mark indicate genes with ambiguous gene name (subfamily indicated).