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Table 5 Significantly enriched GO (gene ontology) functional annotation of predicted target genes of differentially expressed miRNAs during E. coli or S. aureus challenge of MAC-T cells
| GO functional annotation | miRNA | # genes | *P-value (**Benjamini P-Value) | miRNA | # genes | P-value (Benjamini P-Value) |
|---|---|---|---|---|---|---|
| Biological adhesion | Bta-miR-23a | 58 | 0.038 (0.11) | - | - | - |
| Biological regulation | Bta-miR193a-3p | 159 | 0.002 (0.039) | Bta-miR-24-3p | 287 | 0.010 (0.070) |
| Bta-miR365-3p | 142 | 5.5E-5 (3.9E-4) | Bta-miR-148a | 356 | 1.7E-8 (1.3E-7) | |
| Bta-miR-30b-5p/30c | 642 | 4.4E-6 (3.2E-5) | Bta-miR-23a | 565 | 4.0E-9 (4.2E-8) | |
| Bta-miR-499 | 135 | 0.045 (0.11) | Bta-miR-92a | 441 | 7.2E-10 (1.6E-8) | |
| Bta-miR-99b | 31 | 0.007 (0.060) | - | - | - | |
| Cellular component organization | Bta-miR-30b-5p/30c | 235 | 2.4E-4 (0.001) | Bta-miR-2339 | 46 | 0.002 (0.016) |
| Bta-let-7a-5p | 182 | 0.040 (0.120) | Bta-miR-23a | 192 | 0.004 (0.016) | |
| Bta-miR-499 | 60 | 0.001(0.008) | Bta-miR-92a | 144 | 0.016 (0.049) | |
| Bta-miR-148a | 127 | 9.4E-4 (0.005) | Bta-miR-184 | 22 | 0.006 (0.080) | |
| Cellular process | Bta-miR193a-3p | 207 | 0.009 (0.096) | Bta-miR-24-3p | 411 | 1.1E-6 (2.3E-5) |
| Bta-miR423-5p | 337 | 0.034 (0.160) | Bta-miR-148a | 468 | 2.1E-9 (4.7E-8) | |
| Bta-miR365-3p | 180 | 5.7E-4 (0.003) | Bta-miR-2339 | 143 | 0.002 (0.020) | |
| Bta-miR-30b-5p/30c | 889 | 1.1E-10 (2.5E-9) | Bta-miR-23a | 766 | 1.1E-13 (2.4E-12) | |
| Bta-let-7a-5p | 732 | 1.3E-5 (2.5E-4) | Bta-miR-486-5p | 140 | 0.007 (0.067) | |
| Bta-miR-499 | 198 | 8.2E-6 (1.6E-4) | Bta-miR-92a | 567 | 2.0E-7 (1.4E-6) | |
| Bta-miR-99b | 37 | 0.036 (0.100) | - | - | - | |
| Death | Bta-miR193a-3p | 21 | 0.038 (0.190) | Bta-miR-24-3p | 35 | 0.046 (0.220) |
| Bta-miR-30b-5p/30c | 70 | 0.031 (0.083) | Bta-miR-21-3p | 7 | 0.044 (0.930) | |
| Bta-let-7a-5p | 61 | 0.026 (0.087) | Bta-miR-92a | 47 | 0.037 (0.084) | |
| Bta-miR-499 | 21 | 0.014 (0.045) | - | - | - | |
| Developmental process | Bta-miR193a-3p | 71 | 0.028 (0.190) | Bta-miR-24-3p | 151 | 1.0E-5 (1.0E-4) |
| Bta-miR423-5p | 114 | 0.024 (0.150) | Bta-miR-148a | 182 | 3.7E-9 (4.1E-8) | |
| Bta-miR365-3p | 80 | 5.8E-7 (1.3E-5) | Bta-miR-2339 | 57 | 7.1E-4 (0.015) | |
| Bta-miR-30b-5p/30c | 312 | 9.1E-8 (1.0E-6) | Bta-miR-23a | 272 | 2.2E-8 (1.5E-7) | |
| Bta-let-7a-5p | 241 | 0.001 (0.008) | Bta-miR-486-5p | 56 | 0.001 (0.022) | |
| Bta-miR-499 | 74 | 4.1E-4 (0.004) | Bta-miR-92a | 212 | 7.8E-8 (8.5E-7) | |
| Bta-miR-99b | 19 | 0.002 (0.030) | - | - | - | |
| Establishment of localization | Bta-miR423-5p | 110 | 3.4E-4 (0.007) | Bta-let-7a-5p | 205 | 0.004 (0.011) |
| Bta-miR-30b-5p/30c | 243 | 9.9E-4 (0.004) | Bta-miR-92a | 159 | 0.003 (0.009) | |
| Growth | Bta-miR-99b | 4 | 0.016 (0.088) | Bta-miR-23a | 20 | 0.026 (0.088) |
| Localization | Bta-miR423-5p | 119 | 8.8E-4 (0.009) | Bta-miR-148a | 147 | 0.001 (0.005) |
| Bta-miR-30b-5p/30c | 280 | 7.0E-5 (3.9E-4) | Bta-miR-2339 | 49 | 0.015 (0.078) | |
| Bta-let-7a-5p | 233 | 7.2E-4 (0.008) | Bta-miR-92a | 182 | 4.8E-4 (0.002) | |
| Bta-miR-499 | 68 | 0.002 (0.008) | - | - | - | |
| Locomotion | Bta-miR193a-3p | 14 | 0.049 (0.200) | Bta-miR-92a | 31 | 0.030 (0.080) |
| Bta-miR-499 | 17 | 0.002 (0.009) | - | - | - | |
| Metabolic process | Bta-miR365-3p | 139 | 9.6E-4 (0.004) | Bta-miR-148a | 334 | 0.001 (0.006) |
| Bta-let-7a-5p | 538 | 0.001 (0.008) | Bta-miR-23a | 559 | 1.8E-6 (9.7E-6) | |
| Bta-miR-99b | 30 | 0.025 (0.081) | Bta-miR-92a | 395 | 0.039 (0.084) | |
| Multicellular organismal process | Bta-miR365-3p | 94 | 2.3E-5 (2.4E-4) | Bta-miR-24-3p | 167 | 0.050 (0.190) |
| Bta-miR-30b-5p/30c | 372 | 0.001 (0.004) | Bta-miR-148a | 196 | 0.005 (0.015) | |
| Bta-miR-499 | 84 | 0.027 (0.077) | Bta-miR-92a | 258 | 2.2E-5 (1.2-E4) | |
| Bta-miR-99b | 20 | 0.023 (0.095) | - | - | - |
