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Table 5 Significantly enriched GO (gene ontology) functional annotation of predicted target genes of differentially expressed miRNAs during E. coli or S. aureus challenge of MAC-T cells

From: Transcriptome microRNA profiling of bovine mammary epithelial cells challenged with Escherichia coli or Staphylococcus aureusbacteria reveals pathogen directed microRNA expression profiles

GO functional annotation miRNA # genes *P-value (**Benjamini P-Value) miRNA # genes P-value (Benjamini P-Value)
Biological adhesion Bta-miR-23a 58 0.038 (0.11) - - -
Biological regulation Bta-miR193a-3p 159 0.002 (0.039) Bta-miR-24-3p 287 0.010 (0.070)
  Bta-miR365-3p 142 5.5E-5 (3.9E-4) Bta-miR-148a 356 1.7E-8 (1.3E-7)
  Bta-miR-30b-5p/30c 642 4.4E-6 (3.2E-5) Bta-miR-23a 565 4.0E-9 (4.2E-8)
  Bta-miR-499 135 0.045 (0.11) Bta-miR-92a 441 7.2E-10 (1.6E-8)
  Bta-miR-99b 31 0.007 (0.060) - - -
Cellular component organization Bta-miR-30b-5p/30c 235 2.4E-4 (0.001) Bta-miR-2339 46 0.002 (0.016)
Bta-let-7a-5p 182 0.040 (0.120) Bta-miR-23a 192 0.004 (0.016)
  Bta-miR-499 60 0.001(0.008) Bta-miR-92a 144 0.016 (0.049)
  Bta-miR-148a 127 9.4E-4 (0.005) Bta-miR-184 22 0.006 (0.080)
Cellular process Bta-miR193a-3p 207 0.009 (0.096) Bta-miR-24-3p 411 1.1E-6 (2.3E-5)
  Bta-miR423-5p 337 0.034 (0.160) Bta-miR-148a 468 2.1E-9 (4.7E-8)
  Bta-miR365-3p 180 5.7E-4 (0.003) Bta-miR-2339 143 0.002 (0.020)
  Bta-miR-30b-5p/30c 889 1.1E-10 (2.5E-9) Bta-miR-23a 766 1.1E-13 (2.4E-12)
  Bta-let-7a-5p 732 1.3E-5 (2.5E-4) Bta-miR-486-5p 140 0.007 (0.067)
  Bta-miR-499 198 8.2E-6 (1.6E-4) Bta-miR-92a 567 2.0E-7 (1.4E-6)
  Bta-miR-99b 37 0.036 (0.100) - - -
Death Bta-miR193a-3p 21 0.038 (0.190) Bta-miR-24-3p 35 0.046 (0.220)
  Bta-miR-30b-5p/30c 70 0.031 (0.083) Bta-miR-21-3p 7 0.044 (0.930)
  Bta-let-7a-5p 61 0.026 (0.087) Bta-miR-92a 47 0.037 (0.084)
  Bta-miR-499 21 0.014 (0.045) - - -
Developmental process Bta-miR193a-3p 71 0.028 (0.190) Bta-miR-24-3p 151 1.0E-5 (1.0E-4)
Bta-miR423-5p 114 0.024 (0.150) Bta-miR-148a 182 3.7E-9 (4.1E-8)
  Bta-miR365-3p 80 5.8E-7 (1.3E-5) Bta-miR-2339 57 7.1E-4 (0.015)
  Bta-miR-30b-5p/30c 312 9.1E-8 (1.0E-6) Bta-miR-23a 272 2.2E-8 (1.5E-7)
  Bta-let-7a-5p 241 0.001 (0.008) Bta-miR-486-5p 56 0.001 (0.022)
  Bta-miR-499 74 4.1E-4 (0.004) Bta-miR-92a 212 7.8E-8 (8.5E-7)
  Bta-miR-99b 19 0.002 (0.030) - - -
Establishment of localization Bta-miR423-5p 110 3.4E-4 (0.007) Bta-let-7a-5p 205 0.004 (0.011)
Bta-miR-30b-5p/30c 243 9.9E-4 (0.004) Bta-miR-92a 159 0.003 (0.009)
Growth Bta-miR-99b 4 0.016 (0.088) Bta-miR-23a 20 0.026 (0.088)
Localization Bta-miR423-5p 119 8.8E-4 (0.009) Bta-miR-148a 147 0.001 (0.005)
  Bta-miR-30b-5p/30c 280 7.0E-5 (3.9E-4) Bta-miR-2339 49 0.015 (0.078)
  Bta-let-7a-5p 233 7.2E-4 (0.008) Bta-miR-92a 182 4.8E-4 (0.002)
  Bta-miR-499 68 0.002 (0.008) - - -
Locomotion Bta-miR193a-3p 14 0.049 (0.200) Bta-miR-92a 31 0.030 (0.080)
  Bta-miR-499 17 0.002 (0.009) - - -
Metabolic process Bta-miR365-3p 139 9.6E-4 (0.004) Bta-miR-148a 334 0.001 (0.006)
  Bta-let-7a-5p 538 0.001 (0.008) Bta-miR-23a 559 1.8E-6 (9.7E-6)
  Bta-miR-99b 30 0.025 (0.081) Bta-miR-92a 395 0.039 (0.084)
Multicellular organismal process Bta-miR365-3p 94 2.3E-5 (2.4E-4) Bta-miR-24-3p 167 0.050 (0.190)
Bta-miR-30b-5p/30c 372 0.001 (0.004) Bta-miR-148a 196 0.005 (0.015)
  Bta-miR-499 84 0.027 (0.077) Bta-miR-92a 258 2.2E-5 (1.2-E4)
  Bta-miR-99b 20 0.023 (0.095) - - -
  1. *P-Value: The significance of gene-term enrichment with a modified Fisher’s Exact Test.
  2. **Benjamini P-Value: Globally corrects enrichment p-values in order to control family-wide false discovery rate.
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