Table 6 KEGG (Kyoto encyclopedia of genes and genomes) pathways significantly enriched by target genes of 14 out of 17* differentially expressed miRNAs during E. coli or S. aureus challenge of MAC-T cells

Immune system

B cell receptor signaling pathway

X

X

T-cell receptor signaling

X

X

Fc gamma R-mediated, phagocytosis/chemokine signaling

X

X

Signal transduction

MAPK signaling pathway

X

X

X

X

X

X

X

ErbB signaling pathway

X

X

X

X

Wnt signaling pathway

X

X

X

X

X

X

TGF-beta signaling pathway

X

X

X

X

Calcium signaling pathway

X

X

X

Phosphatidylinositol pathway

X

X

ECM-receptor interaction

X

X

Cellular processes (transport and catabolism, cell motility, cell communication)

Endocytosis

X

X

X

Lysosome/apoptosis

X

X

Regulation of actin cytoskeleton

X

X

X

X

X

X

X

Cell cycle

X

X

X

X

P53 signaling pathway

X

X

X

X

Adherens/tight junction

X

X

Focal adhesion

X

X

X

X

X

Endocrine system

Insulin signaling pathway

X

X

Adipocytokine signaling pathway

X

X

GnRH signaling pathway

X

X

X

Melanogenesis

X

X

X

Nervous system

Long term potentiation

X

X

X

X

Neurotrophin signaling pathway

X

X

X

X

X

X

Development: Axon guidance

X

X

X

X

X

X

X

X

X

Metabolism: Glycerophospholipid metabolism/glycosphingolipid biosynthesis

X

X

Human diseases

Pathways in cancer

X

X

X

X

X

X

X

X

X

Colorectal cancer

X

X

X

X

X

X

X

X

Pancreatic cancer

X

X

X

X

Bladder cancer

X

Prostate cancer

X

X

X

X

X

X

Small cell lung cancer

X

X

X

Non-small cell lung cancer

X

X

X

X

Thyroid cancer

X

Renal cell carcinoma

X

X

X

X

Endometrical cancer

X

X

Glioma

X

X

X

X

X

Melanoma

X

X

X

X

Type II diabetes mellitus

X

X

Chronic myeloid leukemia

X

X

X

X

Acute myeloid leukemia

X

X