Data sources, comparison of TF dimer predictions and dimer prediction algorithms. (A) DNase-seq data sources. (B) Comparison of TF dimer predictions obtained using UW and Duke DNase-seq data. The Venn diagram illustrates the overlap between the two sets and also the set of known DNA-binding TF dimers manually compiled from the existing biochemical literature (Figure 1). (C) Comparison of dimer prediction algorithms. SpaMo and iTFs were evaluated both with and without motif trimming. Note that TACO does not require motif trimming. Sensitivity is shown as a function of false positive rate; Area Under Curve (AUC) is indicated.