Genome-wide copy number variant discovery in dogs using the CanineHD genotyping array

BMC Genomics

Table 4 Human-defined dosage sensitive genes within presently identified canine CNVRs

CNVR nr	Chr	Start	Stop	Type	Gene*	Breed	No of affected individuals/total individuals
2	1	65,361,010	65,528,809	del	TRDN	Elkhound	2/12
16	3	93,757,480	94,035,855	dupl	ANAPC13	English Bulldog	2/12
					LCORL
21	4	74,490,811	74,617,835	dupl	NUP155	Golden Retr.Labrador Retr., Flat-coated Retr.	1/12 GR, 1/14 LR, 2/2 FR
					WDR70
25	4	87,386,509	87,831,380	dupl	CDH18	Dachshund	4/12
41	11	12,650,626	13,811,903	dupl	PRR16	Bernese Mountain dog	2/11
52	14	5,305,030	5,752,740	del/dupl	OR14C36	25 breeds	totally 87 affected
					OR14I1	25 breeds
					OR2T1	25 breeds
					OR2T11	25 breeds
					OR2T2	25 breeds
					OR2T27	25 breeds
					OR2T29	25 breeds
					OR2T35	25 breeds
					OR2T4	25 breeds
					OR2T5	25 breeds
					OR2T6	25 breeds
69	19	13,816,712	15,228,649	dupl	PHF17	Chinese Shar-Pei	2/11
106	36	24,468,560	24,970,441	dupl	OSBPL6	Brittany Spaniels, English Setter	2/12 BS, 7/12 ES
					PDE11A
					RBM45
108	37	31,546,053	31,684,318	dupl	SGPP2	Chinese Shar-Pei, Eurasian	10/11 SP, 4/11 E

*Genes in bold are completely within the estimated CNVR boundaries, see also Additional file 1: Table S6.

ISSN: 1471-2164