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Table 7 Substrate and coenzyme-interacting residues in amphibian, reptilian and avian ADH7

From: The Xenopusalcohol dehydrogenase gene family: characterization and comparative analysis incorporating amphibian and reptilian genomes

Enzyme

Substrate-binding

Coenzyme-binding

Inner

Middle

Outer

     

48

93

140

141

57

115

116

142

294

318

110

306

309

47

48

51

269

271

 X. tropicalis ADH7

T

C

F

L

L

H

L

W

E

I

C

I

F

R

T

H

I

N

 Turtle ADH7

T

C

F

L

L

H

L

W

T

F

C

M

F

R

T

H

I

R

 Anole ADH7A

T

C

L

M

F

H

F

W

E

C

C

V

I

R

T

H

I

L

 Anole ADH7B

T

C

F

L

F

H

L

W

V

F

C

M

F

G

T

H

V

C

 Anole ADH7C

T

C

F

L

F

H

I

W

A

L

C

L

L

R

T

N

I

R

 Chicken ADH7

T

P

F

L

F

H

L

W

V

L

Y

F

L

H

T

H

I

T

 Zebra finch ADH7

T

C

Y

L

L

H

F

W

V

L

Y

V

L

H

T

H

I

H

 Pigeon ADH7

T

C

F

M

I

H

F

W

V

L

Y

L

L

R

T

H

I

R

  1. Residues 115 and 142, involved in the rearrangement of the loop 112–120 at the entrance of the substrate-binding pocket and present in all ADH7 forms, are also included. Residues at positions 223-224-225 are D-I-N in all cases.
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BMC Genomics

ISSN: 1471-2164

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