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Table 7 Substrate and coenzyme-interacting residues in amphibian, reptilian and avian ADH7

From: The Xenopusalcohol dehydrogenase gene family: characterization and comparative analysis incorporating amphibian and reptilian genomes

Enzyme Substrate-binding Coenzyme-binding
Inner Middle Outer      
48 93 140 141 57 115 116 142 294 318 110 306 309 47 48 51 269 271
 X. tropicalis ADH7 T C F L L H L W E I C I F R T H I N
 Turtle ADH7 T C F L L H L W T F C M F R T H I R
 Anole ADH7A T C L M F H F W E C C V I R T H I L
 Anole ADH7B T C F L F H L W V F C M F G T H V C
 Anole ADH7C T C F L F H I W A L C L L R T N I R
 Chicken ADH7 T P F L F H L W V L Y F L H T H I T
 Zebra finch ADH7 T C Y L L H F W V L Y V L H T H I H
 Pigeon ADH7 T C F M I H F W V L Y L L R T H I R
  1. Residues 115 and 142, involved in the rearrangement of the loop 112–120 at the entrance of the substrate-binding pocket and present in all ADH7 forms, are also included. Residues at positions 223-224-225 are D-I-N in all cases.