|
Enzyme
|
Substrate-binding
|
Coenzyme-binding
|
|---|
|
Inner
|
Middle
|
Outer
| | | | | |
|---|
|
48
|
93
|
140
|
141
|
57
|
115
|
116
|
142
|
294
|
318
|
110
|
306
|
309
|
47
|
48
|
51
|
269
|
271
|
|---|
|
X. tropicalis ADH7
|
T
|
C
|
F
|
L
|
L
|
H
|
L
|
W
|
E
|
I
|
C
|
I
|
F
|
R
|
T
|
H
|
I
|
N
|
|
Turtle ADH7
|
T
|
C
|
F
|
L
|
L
|
H
|
L
|
W
|
T
|
F
|
C
|
M
|
F
|
R
|
T
|
H
|
I
|
R
|
|
Anole ADH7A
|
T
|
C
|
L
|
M
|
F
|
H
|
F
|
W
|
E
|
C
|
C
|
V
|
I
|
R
|
T
|
H
|
I
|
L
|
|
Anole ADH7B
|
T
|
C
|
F
|
L
|
F
|
H
|
L
|
W
|
V
|
F
|
C
|
M
|
F
|
G
|
T
|
H
|
V
|
C
|
|
Anole ADH7C
|
T
|
C
|
F
|
L
|
F
|
H
|
I
|
W
|
A
|
L
|
C
|
L
|
L
|
R
|
T
|
N
|
I
|
R
|
|
Chicken ADH7
|
T
|
P
|
F
|
L
|
F
|
H
|
L
|
W
|
V
|
L
|
Y
|
F
|
L
|
H
|
T
|
H
|
I
|
T
|
|
Zebra finch ADH7
|
T
|
C
|
Y
|
L
|
L
|
H
|
F
|
W
|
V
|
L
|
Y
|
V
|
L
|
H
|
T
|
H
|
I
|
H
|
|
Pigeon ADH7
|
T
|
C
|
F
|
M
|
I
|
H
|
F
|
W
|
V
|
L
|
Y
|
L
|
L
|
R
|
T
|
H
|
I
|
R
|
- Residues 115 and 142, involved in the rearrangement of the loop 112–120 at the entrance of the substrate-binding pocket and present in all ADH7 forms, are also included. Residues at positions 223-224-225 are D-I-N in all cases.
