Table 3 Functional annotations of putative secreted uterine proteins that are up-regulated when a hard-shelled egg is present

SPP1* (395210)

Secreted phosphoprotein 1 (osteopontin), involved in bone mineralization and present in chicken eggshell

PENK* (421131)

Proenkephalin

COL1A2* (396243)

Collagen, type I, alpha 2

DCN** (417892)

Decorin, leucine-rich repeats (LRRs) participate in protein-protein interactions

SPARCL1** (422586)

SPARC-like 1 (hevin), extracellular Ca2+ binding domain (containing 2 EF-hand motifs), serine protease inhibitor

CD34** (419856)

CD34 molecule, podocalyxin, sialoprotein highly negatively charged

CRELD2** (417735)

Cysteine-rich with calcium binding EGF-like domains 2

MCFD2** (421413)

Multiple coagulation factor deficiency 2, contains calcium-binding EF-hand

MATN2*** (426584)

Matrilin 2, calcium-binding EGF-like domain, mediate cell-matrix and matrix-matrix interactions in cartilaginous

SLIT2* (373967)

Slit homolog 2 (Drosophila), developmental biology with EGF domains includng calcium binding domains

HS6ST2* (395150)

Heparan sulfate 6-O-sulfotransferase 2

EXT1*** (420283)

Exostosin 1, involved in glycosaminoglycans biosynthesis

MGAT4B** (416285)

Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B, N-Glycan biosynthesis

TSKU* (419088)

Tsukushi small leucine rich proteoglycan homolog, protein-protein interactions

GPC1* (424770)

Glypican 1

ADAMTS1** (418479)

ADAM metallopeptidase with thrombospondin type 1 motif, 1

CLU* (395722)

Clusterin, molecular chaperone

GKN2-OCX21* (419515)

Gastrokine 2 (ovocalyxin-21), eggshell specific protein, brichos domain, molecular chaperone

HSPA5* (396487)

Heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa), chaperone help to fold many proteins

HSPA13** (418469)

Heat shock protein 70 kDa family, member 13, molecular chaperone

HSP90B1** (374163)

Endoplasmin, heat shock protein 90 kDa beta (Grp94), member 1, molecular chaperone

HYOU1* (428251)

Hypoxia up-regulated 1, HSP protein, molecular chaperone

ERLEC1* (421220)

Endoplasmic reticulum lectin 1

DNAJB9** (417783)

DnaJ/Hsp40 (heat shock protein 40) proteins, crucial roles in protein translation, folding, unfolding, translocation, and degradation, molecular chaperone

FICD** (416889)

FIC domain containing tetratricopeptide repeat domain involved in variety of functions including protein-protein interactions, molecular chaperone

GRIP2** (416043)

Glutamate receptor interacting protein 2, involved in protein-protein interactions

OCX36* (419289)

Ovocalyxin-36, LBP/BPI protein, antimicrobial

BPIL3** (419290)

Bactericidal/permeability-increasing protein-like 3, LBP/BPI protein, antimicrobial

LY86* (420872)

Lymphocyte antigen 86, involved in innate immune response and binding to bacterial LPS

PTN* (418125)

Pleiotrophin, heparin binding protein, antimicrobial

SEMA3C* (374090)

Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C, developmental biology

LOC422316** (422316)

Vascular endothelial growth factor receptor kdr-like, IG-like domain

PROC** (395085)

Protein C (inactivator of coagulation factors), trypsin-like serine protease with EGF-like calcium binding domain

P4HA1** (423704)

Prolyl 4-hydroxylase, alpha polypeptide I

SPON1* (395657)

Spondin 1, extracellular matrix protein involved in patterning axonal growth trajectory

POMC* (422011)

Proopiomelanocortin

SEMA6D* (415430)

Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, involved in the development of the nervous system and in axonal guidance

P4HB* (374091)

Prolyl 4-hydroxylase, beta polypeptide, containing thiredoxin domain

PRDX4* (418601)

Peroxiredoxin 4

FAM3C* (417758)

Family with sequence similarity 3, member C

LOC776741** (776741)

Uncharacterized LOC776741

RET** (396107)

Ret proto-oncogene, cadherin repeat-like domain involved in cell-cell contact when bound to calcium

GREM1** (395826)

Gremlin 1, extracellular DAN domain

WNT11** (395562)

Wingless-type MMTV integration site family, member 11

ROS1** (396192)

C-ros oncogene 1 receptor tyrosine kinase, contains Fibronectin type 3 and protein Tyrosine Kinase domains

ERP29** (416882)

Endoplasmic reticulum protein 29, thioredoxin domain, oxidoreductase

COMT** (416783)

Catechol-O-methyltransferase

CCDC80** (395074)

Coiled-coil domain containing 80 involved in cell adhesion;

PDGFD** (418978)

Platelet derived growth factor D, biology of development

ERO1LB** (421509)

ERO1-like beta (S. cerevisiae)

PDIA6** (421940)

Protein disulfide isomerase family A, member 6, contains thioredoxin domain

MANF** (770664)

Mesencephalic astrocyte-derived neurotrophic factor, RNA binding protein

CYP26A1** (408183)

Cytochrome P450, family 26, subfamily A, polypeptide 1 involved in the oxidative degradation of various compound

AGR2** (420596)

Anterior gradient homolog 2 (Xenopus laevis), containing Thiroedoxin domain

TNFRSF6B** (395096)

Tumor necrosis factor receptor superfamily domain, involved in nvolved in inflammation response, apoptosis, autoimmunity and organogenesis

PCDH19** (422263)

Protocadherin 19, Cadherin tandem repeat domain involved in Ca2 + −mediated cell-cell adhesion

PDIA3 ** (373899)

Protein disulfide isomerase family A, member 3, containing thiroedoxin domain