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Table 3 Functional annotations of putative secreted uterine proteins that are up-regulated when a hard-shelled egg is present

From: Hen uterine gene expression profiling during eggshell formation reveals putative proteins involved in the supply of minerals or in the shell mineralization process

Potential functions Gene symbol (Gene Id) Gene description
Mineralization Interactions with calcium SPP1* (395210) Secreted phosphoprotein 1 (osteopontin), involved in bone mineralization and present in chicken eggshell
PENK* (421131) Proenkephalin
COL1A2* (396243) Collagen, type I, alpha 2
DCN** (417892) Decorin, leucine-rich repeats (LRRs) participate in protein-protein interactions
SPARCL1** (422586) SPARC-like 1 (hevin), extracellular Ca2+ binding domain (containing 2 EF-hand motifs), serine protease inhibitor
CD34** (419856) CD34 molecule, podocalyxin, sialoprotein highly negatively charged
CRELD2** (417735) Cysteine-rich with calcium binding EGF-like domains 2
MCFD2** (421413) Multiple coagulation factor deficiency 2, contains calcium-binding EF-hand
MATN2*** (426584) Matrilin 2, calcium-binding EGF-like domain, mediate cell-matrix and matrix-matrix interactions in cartilaginous
  SLIT2* (373967) Slit homolog 2 (Drosophila), developmental biology with EGF domains includng calcium binding domains
Proteoglycans HS6ST2* (395150) Heparan sulfate 6-O-sulfotransferase 2
EXT1*** (420283) Exostosin 1, involved in glycosaminoglycans biosynthesis
MGAT4B** (416285) Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B, N-Glycan biosynthesis
TSKU* (419088) Tsukushi small leucine rich proteoglycan homolog, protein-protein interactions
GPC1* (424770) Glypican 1
  ADAMTS1** (418479) ADAM metallopeptidase with thrombospondin type 1 motif, 1
Molecular chaperone CLU* (395722) Clusterin, molecular chaperone
GKN2-OCX21* (419515) Gastrokine 2 (ovocalyxin-21), eggshell specific protein, brichos domain, molecular chaperone
HSPA5* (396487) Heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa), chaperone help to fold many proteins
HSPA13** (418469) Heat shock protein 70 kDa family, member 13, molecular chaperone
HSP90B1** (374163) Endoplasmin, heat shock protein 90 kDa beta (Grp94), member 1, molecular chaperone
HYOU1* (428251) Hypoxia up-regulated 1, HSP protein, molecular chaperone
ERLEC1* (421220) Endoplasmic reticulum lectin 1
DNAJB9** (417783) DnaJ/Hsp40 (heat shock protein 40) proteins, crucial roles in protein translation, folding, unfolding, translocation, and degradation, molecular chaperone
FICD** (416889) FIC domain containing tetratricopeptide repeat domain involved in variety of functions including protein-protein interactions, molecular chaperone
  GRIP2** (416043) Glutamate receptor interacting protein 2, involved in protein-protein interactions
Antimicrobial proteins OCX36* (419289) Ovocalyxin-36, LBP/BPI protein, antimicrobial
BPIL3** (419290) Bactericidal/permeability-increasing protein-like 3, LBP/BPI protein, antimicrobial
LY86* (420872) Lymphocyte antigen 86, involved in innate immune response and binding to bacterial LPS
PTN* (418125) Pleiotrophin, heparin binding protein, antimicrobial
SEMA3C* (374090) Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C, developmental biology
  LOC422316** (422316) Vascular endothelial growth factor receptor kdr-like, IG-like domain
SERPIN PROC** (395085) Protein C (inactivator of coagulation factors), trypsin-like serine protease with EGF-like calcium binding domain
Other roles P4HA1** (423704) Prolyl 4-hydroxylase, alpha polypeptide I
SPON1* (395657) Spondin 1, extracellular matrix protein involved in patterning axonal growth trajectory
POMC* (422011) Proopiomelanocortin
SEMA6D* (415430) Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, involved in the development of the nervous system and in axonal guidance
P4HB* (374091) Prolyl 4-hydroxylase, beta polypeptide, containing thiredoxin domain
PRDX4* (418601) Peroxiredoxin 4
FAM3C* (417758) Family with sequence similarity 3, member C
LOC776741** (776741) Uncharacterized LOC776741
RET** (396107) Ret proto-oncogene, cadherin repeat-like domain involved in cell-cell contact when bound to calcium
GREM1** (395826) Gremlin 1, extracellular DAN domain
WNT11** (395562) Wingless-type MMTV integration site family, member 11
ROS1** (396192) C-ros oncogene 1 receptor tyrosine kinase, contains Fibronectin type 3 and protein Tyrosine Kinase domains
ERP29** (416882) Endoplasmic reticulum protein 29, thioredoxin domain, oxidoreductase
COMT** (416783) Catechol-O-methyltransferase
CCDC80** (395074) Coiled-coil domain containing 80 involved in cell adhesion;
PDGFD** (418978) Platelet derived growth factor D, biology of development
ERO1LB** (421509) ERO1-like beta (S. cerevisiae)
PDIA6** (421940) Protein disulfide isomerase family A, member 6, contains thioredoxin domain
MANF** (770664) Mesencephalic astrocyte-derived neurotrophic factor, RNA binding protein
CYP26A1** (408183) Cytochrome P450, family 26, subfamily A, polypeptide 1 involved in the oxidative degradation of various compound
AGR2** (420596) Anterior gradient homolog 2 (Xenopus laevis), containing Thiroedoxin domain
TNFRSF6B** (395096) Tumor necrosis factor receptor superfamily domain, involved in nvolved in inflammation response, apoptosis, autoimmunity and organogenesis
PCDH19** (422263) Protocadherin 19, Cadherin tandem repeat domain involved in Ca2 + −mediated cell-cell adhesion
  PDIA3 ** (373899) Protein disulfide isomerase family A, member 3, containing thiroedoxin domain
  1. *Predicted to be secreted and already identified in the eggshell.
  2. **Predicted to be secreted but not previously identified in the eggshell.
  3. ***Proteins already identified in the eggshell, but not predicted to be secreted.