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Table 2 Summary of the GO analysis of 31 differentially expressed genes between the mammary gland of two cows with high milk protein and fat percentage and two cows with low protein and fat percentage

From: Transcriptional profiling of mammary gland in Holstein cows with extremely different milk protein and fat percentage using RNA sequencing

GO ID

GO term

No. of differentially expressed genes

P-value

GO:0034364

High-density lipoprotein particle

4

3.26E-06

GO:0006953

Acute-phase response

4

3.26E-06

GO:0001938

Positive regulation of endothelial cell proliferation

3

3.50E-05

GO:0035767

Endothelial cell chemotaxis

2

5.11E-05

GO:0043129

Surfactant homeostasis

3

0.000120

GO:0002042

Cell migration involved in sprouting angiogenesis

2

0.000126

GO:0035924

Cellular response to vascular endothelial growth factor stimulus

2

0.000224

GO:0007050

Cell cycle arrest

4

0.000321

GO:0043498

Cell surface binding

3

0.000347

GO:0030855

Epithelial cell differentiation

3

0.001532

GO:2000016

Negative regulation of determination of dorsal identity

1

0.001848

GO:0019912

cyclin-dependent protein kinase activating kinase activity

1

0.001848

GO:0001791

IgM binding

1

0.001848

GO:0002575

Basophil chemotaxis

1

0.001848

GO:0043184

Vascular endothelial growth factor receptor 2 binding

1

0.001848

GO:0005576

Extracellular region

9

0.002867

GO:0043433

Negative regulation of sequence-specific DNA-binding transcription factor activity

3

0.003109

GO:2000278

Regulation of DNA biosynthetic process

1

0.003694

GO:0070557

PCNA-p21 complex

1

0.003694

GO:0043183

Vascular endothelial growth factor receptor 1 binding

1

0.003694

GO:0002368

B-cell cytokine production

2

0.003694

GO:0030135

Coated vesicle

2

0.003694

GO:0048291

Isotype switching to IgG isotypes

2

0.003694

GO:0019862

IgA binding

1

0.003694

GO:0060649

Mammary gland bud elongation

2

0.003694

GO:0060659

Nipple sheath formation

2

0.003694

GO:0060319

Primitive erythrocyte differentiation

1

0.003694

GO:0042789

mRNA transcription from RNA polymerase II promoter

1

0.003694

GO:0010827

Regulation of glucose transport

1

0.003694

GO:0005172

Vascular endothelial growth factor receptor binding

1

0.003704

GO:0051451

Myoblast migration

1

0.003712

GO:0050731

Positive regulation of peptidyl-tyrosine phosphorylation

2

0.004336

GO:0002842

Positive regulation of T-cell-mediated immune response to tumor cell

2

0.005536

GO:0042026

Protein refolding

2

0.005536

GO:0033158

Regulation of protein import into nucleus, translocation

1

0.005537

GO:0055106

Ubiquitin-protein ligase regulator activity

1

0.005537

GO:0071603

Endothelial cell-cell adhesion

1

0.005554

GO:0015204

Urea transmembrane transporter activity

2

0.005573

GO:0071918

Urea transmembrane transport

2

0.005573

GO:0018401

Peptidyl-proline hydroxylation to 4-hydroxy-L-proline

1

0.005604

GO:0030141

Stored secretory granule

4

0.006394

GO:0002755

MyD88-dependent toll-like receptor signaling pathway

2

0.007375

GO:0015840

Urea transport

2

0.007376

GO:0005372

Water transmembrane transporter activity

2

0.007376

GO:0090050

Positive regulation of cell migration involved in sprouting angiogenesis

1

0.007379

GO:0050927

Positive regulation of positive chemotaxis

1

0.007385

GO:0060754

Positive regulation of mast cell chemotaxis

1

0.007434

GO:0031077

Post-embryonic camera-type eye development

1

0.007435

GO:0043117

Positive regulation of vascular permeability

1

0.007439

GO:0010740

Positive regulation of intracellular protein kinase cascade

1

0.007509

GO:0008201

Heparin binding

2

0.007540

GO:0007220

Notch receptor processing

1

0.007634

GO:0005769

Early endosome

3

0.008615

GO:0046696

Lipopolysaccharide receptor complex

2

0.009213

GO:0043405

Regulation of MAP kinase activity

1

0.009217

GO:0051428

Peptide hormone receptor binding

2

0.009221

GO:0032793

Positive regulation of CREB transcription factor activity

1

0.009358