Table 2 Genes related to the immune system and exhibited Semax-induced alteration of expression levels

3h

MHC (major histocompatibility class) I and II:

RT1 class I, CE15 (RT1-CE15), mRNA.

RT1-CE15

414789

0.43

4.0E-06

RT1 class I, M6, gene 2 (RT1-M6-2), mRNA.

RT1-M6-2

365527

0.64

3.0E-03

RT1 class II, locus Db1 (RT1-Db1), mRNA.

RT1-Db1

294270

0.55

7.6E-04

RT1 class II, locus Ba, mRNA.

RT1-Ba

309621

0.51

3.1E-07

CD74 antigen (invariant polpypeptide of MHC class II antigen-associated), mRNA.

Cd74

25599

0.50

1.6E-09

RT1 class Ia, locus A1, mRNA.

RT1-A1

24973

0.50

7.6E-10

histocompatibility 2, class II antigen E alpha, mRNA.

H2-Ea

294269

0.49

4.1E-10

Others:

Prostaglandin-endoperoxide synthase 2, mRNA.

Ptgs2/Cox2

29527

2.00

8.3E-34

Intercellular adhesion molecule 1, mRNA.

Icam1

25464

1.61

9.9E-05

24h

Genes related to the immune system (36 genes):

immunoglobulins:

Similar to immunoglobulin heavy chain variable region, mRNA.

LOC500734

500734

15.37

7.5E-11

Similar to immunoglobulin kappa-chain, mRNA.

LOC500172

500172

11.57

2.1E-34

Similar to Immunoglobulin kappa-chain VJ precursor, mRNA.

LOC500161

500161

8.31

2.1E-34

Similar to gamma-2a immunoglobulin heavy chain, mRNA.

LOC362796

362796

8.20

2.1E-34

Similar to immunoglobulin heavy chain variable region, mRNA.

LOC314492

314492

6.53

2.0E-06

Similar to immunoglobulin kappa-chain, mRNA.

LOC500194

500194

6.27

2.1E-34

Similar to Immunoglobulin kappa-chain VJ precursor, mRNA.

LOC502789

502789

6.00

3.7E-20

Similar to immunoglobulin kappa-chain, mRNA.

LOC502843

502843

5.74

1.7E-19

Similar to immunoglobulin kappa-chain, mRNA.

LOC502797

502797

5.48

5.5E-11

Similar to IG kappa-chain V-V region K2 precursor, mRNA.

LOC500180

500180

4.67

4.8E-08

Similar to Igh-1a_predicted protein, mRNA.

LOC503073

503073

3.67

7.3E-14

Similar to NGF-binding Ig light chain, mRNA.

LOC502820

502820

3.60

5.6E-23

Similar to immunoglobulin heavy chain variable region, mRNA.

LOC500733

500733

3.08

5.3E-14

Immunoglobulin heavy chain 1a (serum IgG2a), mRNA.

Igh-1a

299352

2.97

3.5E-26

Similar to NGF-binding Ig light chain, mRNA.

LOC500183

500183

2.91

3.8E-22

Similar to Immunoglobulin kappa-chain VJ precursor, mRNA.

LOC500162

500162

2.80

1.7E-04

Similar to immunoglobulin heavy chain variable region, mRNA.

LOC503070

503070

2.70

1.6E-03

Similar to Immunoglobulin kappa-chain VJ precursor, mRNA.

LOC500163

500163

2.62

8.6E-03

Similar to immunoglobulin light chain variable region, mRNA.

LOC363828

363828

2.52

9.7E-03

Similar to IG light chain Vk region Y13-259, mRNA.

LOC500181

500181

1.85

3.2E-07

Similar to Ig kappa light chain precursor, mRNA.

LOC500177

500177

1.76

3.2E-06

Similar to immunoglobulin light chain variable region, mRNA.

LOC502831

502831

0.34

6.3E-06

Chemokines:

Chemokine (C-X-C motif) ligand 13, mRNA.

Cxcl13

498335

4.12

1.6E-08

Chemokine (C-X-C motif) ligand 9, mRNA.

Cxcl9

246759

2.42

1.8E-14

Chemokine (C-X-C motif) ligand 10, mRNA.

Cxcl10

245920

2.32

1.9E-03

Chemokine (C-C motif) ligand 5, mRNA.

Ccl5

81780

1.98

6.5E-05

Chemokine (C-X-C motif) ligand 11, mRNA.

Cxcl11

305236

1.85

2.1E-03

Chemokine (C-C motif) ligand 7, mRNA.

Ccl7

287561

1.78

8.3E-04

Chemokine (C-C motif) ligand 19, mRNA.

Ccl19

362506

1.72

3.4E-05

Chemokine (C-C motif) ligand 20, mRNA.

Ccl20

29538

0.44

3.4E-05

MHC (major histocompatibility class) I and II:

RT1 class II, locus Ba, mRNA.

RT1-Ba

309621

2.28

1.5E-15

RT1 class I, A3, mRNA.

RT1-A3

309627

1.96

4.6E-06

RT1 class Ia, locus A1, mRNA.

RT1-A1

24973

1.94

2.8E-11

RT1 class I, T24, gene 4, mRNA.

RT1-149

414784

1.86

3.8E-10

Histocompatibility 2, M region locus 10.6, mRNA.

H2-M10.6

414787

1.77

2.0E-06

CD74 antigen (invariant polpypeptide of MHC class II antigen-associated), mRNA.

Cd74

25599

1.63

5.3E-06